端粒酶疗法逆转心血管衰老
Telomerase Therapy to Reverse Cardiovascular Senescence.
作者信息
Nazari-Shafti Timo Z, Cooke John P
机构信息
Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas.
出版信息
Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):172-5. doi: 10.14797/mdcj-11-3-172.
Abstract
Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.
摘要
内皮细胞的细胞衰老在最终导致动脉粥样硬化斑块的血管病变发展中起重要作用。本综述重点关注促成血管疾病的内皮细胞和血管平滑肌细胞的年龄相关变化，并讨论可能使血管系统恢复活力从而预防或延缓动脉粥样硬化的潜在新靶点。
相似文献
1
Telomerase Therapy to Reverse Cardiovascular Senescence.
Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):172-5. doi: 10.14797/mdcj-11-3-172.
2
Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy.
Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):166-71. doi: 10.14797/mdcj-11-3-166.
3
Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.
Atherosclerosis. 2015 Dec;243(2):438-48. doi: 10.1016/j.atherosclerosis.2015.10.020. Epub 2015 Oct 19.
4
Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):790-800. doi: 10.1161/ATVBAHA.113.303116. Epub 2014 Feb 13.
5
HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL.
Med Hypotheses. 2008;70(2):338-42. doi: 10.1016/j.mehy.2007.05.025. Epub 2007 Jul 20.
6
Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis.
Atherosclerosis. 2011 May;216(1):23-34. doi: 10.1016/j.atherosclerosis.2011.02.011. Epub 2011 Feb 17.
7
Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.
Circ Res. 2006 Jul 21;99(2):156-64. doi: 10.1161/01.RES.0000233315.38086.bc. Epub 2006 Jun 22.
8
Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence.
Biochim Biophys Acta. 2007 Jan;1772(1):72-80. doi: 10.1016/j.bbadis.2006.10.004. Epub 2006 Oct 12.
9
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.
Circ Res. 2004 Apr 2;94(6):768-75. doi: 10.1161/01.RES.0000121104.05977.F3. Epub 2004 Feb 12.
10
Role of Telomeres Shortening in Atherogenesis: An Overview.
Cells. 2021 Feb 15;10(2):395. doi: 10.3390/cells10020395.
引用本文的文献
1
Circular RNA Telomerase Reverses Endothelial Senescence in Progeria.
Aging Cell. 2025 Jun;24(6):e70021. doi: 10.1111/acel.70021. Epub 2025 Feb 23.
2
Endothelial-specific telomerase inactivation causes telomere-independent cell senescence and multi-organ dysfunction characteristic of aging.
Aging Cell. 2024 Jun;23(6):e14138. doi: 10.1111/acel.14138. Epub 2024 Mar 12.
3
Gene expression in mice with endothelium-specific telomerase knockout.
Front Cell Dev Biol. 2023 Dec 7;11:1295072. doi: 10.3389/fcell.2023.1295072. eCollection 2023.
4
Bistability of Dielectrically Anisotropic Nematic Crystals and the Adaptation of Endothelial Collectives to Stress Fields.
Adv Sci (Weinh). 2022 May;9(16):e2102148. doi: 10.1002/advs.202102148. Epub 2022 Mar 28.
5
Melatonin Alleviates Age-Associated Endothelial Injury of Atherosclerosis via Regulating Telomere Function.
J Inflamm Res. 2021 Dec 11;14:6799-6812. doi: 10.2147/JIR.S329020. eCollection 2021.
6
Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications.
Antioxid Redox Signal. 2021 Oct 20;35(12):974-1015. doi: 10.1089/ars.2021.0031. Epub 2021 Sep 17.
7
Role of Telomeres Shortening in Atherogenesis: An Overview.
Cells. 2021 Feb 15;10(2):395. doi: 10.3390/cells10020395.
8
The Effects of Resistance Exercise With Blood Flow Restriction on Flow-Mediated Dilation and Arterial Stiffness in Elderly People With Low Gait Speed: Protocol for a Randomized Controlled Trial.
JMIR Res Protoc. 2019 Nov 1;8(11):e14691. doi: 10.2196/14691.
9
Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.
Redox Biol. 2020 Jan;28:101304. doi: 10.1016/j.redox.2019.101304. Epub 2019 Aug 22.
10
Aging: Molecular Pathways and Implications on the Cardiovascular System.
Oxid Med Cell Longev. 2017;2017:7941563. doi: 10.1155/2017/7941563. Epub 2017 Aug 9.
本文引用的文献
1
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells.
FASEB J. 2015 May;29(5):1930-9. doi: 10.1096/fj.14-259531. Epub 2015 Jan 22.
2
Human telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas.
Anticancer Res. 2014 Nov;34(11):6389-95.
3
mRNA-based therapeutics--developing a new class of drugs.
Nat Rev Drug Discov. 2014 Oct;13(10):759-80. doi: 10.1038/nrd4278. Epub 2014 Sep 19.
4
Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment.
Atherosclerosis. 2014 Nov;237(1):45-52. doi: 10.1016/j.atherosclerosis.2014.08.036. Epub 2014 Aug 28.
5
A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.
PLoS One. 2014 Jul 24;9(7):e102186. doi: 10.1371/journal.pone.0102186. eCollection 2014.
6
Telomerase modulation in therapeutic approach.
Curr Pharm Des. 2014;20(41):6438-51. doi: 10.2174/1381612820666140630092721.
7
Proinflammation: the key to arterial aging.
Trends Endocrinol Metab. 2014 Feb;25(2):72-9. doi: 10.1016/j.tem.2013.10.002. Epub 2013 Dec 20.
8
The hallmarks of aging.
Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.
9
Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation.
Int Immunopharmacol. 2013 Jun;16(2):261-7. doi: 10.1016/j.intimp.2013.04.003. Epub 2013 Apr 15.
10
Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions.
Nat Nanotechnol. 2013 Jan;8(1):61-8. doi: 10.1038/nnano.2012.212. Epub 2012 Dec 16.
Zotero 插件