Stahl Ulrike, Keir Nancy J, Landers Alan, Jones Lyndon W
*PhD, Dipl-AO †PhD, OD, FAAO ‡OD, MS, FAAO §PhD, FCOptom, FAAO Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada (US, NJK, LWJ); and Alcon Laboratories Inc., Johns Creek, Texas (AL).
Optom Vis Sci. 2016 Aug;93(8):861-71. doi: 10.1097/OPX.0000000000000912.
To assess the impact of lens-free intervals of varying lengths on end-of-day comfort with soft contact lenses.
Twenty-five symptomatic lens wearers participated in this randomized, cross-over study involving nine individual 12-hour days: one spectacle (no lens) and eight lens wear days. On each lens wear day, lenses were worn bilaterally in 2-hour intervals, separated by lens-free (recovery) periods of 0, 30, 60, or 80 minutes (repeated throughout the day). For each 2-hour lens wear interval, new lenses were worn. Ocular comfort was rated on a 0 to 100 visual analogue scale (0 = extremely uncomfortable); tear film and ocular parameters were assessed at the beginning and end of each study day. This study involved two different types of silicone hydrogel lenses, and the order of lens type and length of recovery period was randomized. Participants were unaware of the true study purpose and that a new lens pair was used for each lens wear interval.
End-of-day comfort on lens wear days was significantly worse than on the spectacle day (p < 0.002). There was no significant effect of the recovery periods on end-of-day comfort (p > 0.05). Although lens wear affected noninvasive tear film break-up time and conjunctival staining, there were no effects of recovery period length on noninvasive tear film break-up time (p > 0.05), tear meniscus height (p > 0.05), corneal staining (p > 0.05), conjunctival staining (p > 0.05), bulbar conjunctival redness (p > 0.05), or limbal redness (p > 0.05). There was no consistent effect of recovery period length on lid margin staining.
Lens-free recovery periods during a 12-hour lens wear day did not positively impact end-of-day comfort in this study. Cumulative lens wear times ranged from 8 to 12 hours, and the results suggest that once the length of lens wear exceeds the usual comfortable wear time, there is no benefit of short recovery periods.
评估不同时长的无镜片间隔时间对软性隐形眼镜佩戴至一天结束时舒适度的影响。
25名有症状的隐形眼镜佩戴者参与了这项随机交叉研究,研究为期9个独立的12小时日:一天戴框架眼镜(不戴隐形眼镜),八天戴隐形眼镜。在每个戴隐形眼镜日,双眼佩戴隐形眼镜,每次佩戴2小时,中间间隔0、30、60或80分钟的无镜片(恢复)期(全天重复)。对于每2小时的隐形眼镜佩戴间隔,均佩戴新的隐形眼镜。采用0至100的视觉模拟量表对眼部舒适度进行评分(0 = 极度不适);在每个研究日开始和结束时评估泪膜和眼部参数。本研究涉及两种不同类型的硅水凝胶隐形眼镜,隐形眼镜类型和恢复期长度的顺序是随机的。参与者不知道该研究的真正目的,也不知道每个隐形眼镜佩戴间隔都使用了一副新的隐形眼镜。
戴隐形眼镜日结束时的舒适度明显低于戴框架眼镜日(p < 0.002)。恢复期对一天结束时的舒适度没有显著影响(p > 0.05)。虽然隐形眼镜佩戴会影响非侵入性泪膜破裂时间和结膜染色,但恢复期长度对非侵入性泪膜破裂时间(p > 0.05)、泪液弯月面高度(p > 0.05)、角膜染色(p > 0.05)、结膜染色(p > 0.05)、球结膜充血(p > 0.05)或角膜缘充血(p > 0.05)均无影响。恢复期长度对睑缘染色没有一致的影响。
在本研究中,12小时隐形眼镜佩戴日中的无镜片恢复期对一天结束时的舒适度没有积极影响。累计隐形眼镜佩戴时间为8至12小时,结果表明,一旦隐形眼镜佩戴时间超过通常的舒适佩戴时间,短时间的恢复期并无益处。