• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用硬X射线折射率计算机断层扫描检测乳腺癌的治疗后效果——一项可行性研究

Detection of Post-Therapeutic Effects in Breast Carcinoma Using Hard X-Ray Index of Refraction Computed Tomography - A Feasibility Study.

作者信息

Grandl Susanne, Sztrókay-Gaul Anikó, Mittone Alberto, Gasilov Sergey, Brun Emmanuel, Bravin Alberto, Mayr Doris, Auweter Sigrid D, Hellerhoff Karin, Reiser Maximilian, Coan Paola

机构信息

Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Munich, Germany.

Department of Physics, Ludwig-Maximilians-University, Garching, Germany.

出版信息

PLoS One. 2016 Jun 30;11(6):e0158306. doi: 10.1371/journal.pone.0158306. eCollection 2016.

DOI:10.1371/journal.pone.0158306
PMID:27362638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4928822/
Abstract

OBJECTIVES

Neoadjuvant chemotherapy is the state-of-the-art treatment in advanced breast cancer. A correct visualization of the post-therapeutic tumor size is of high prognostic relevance. X-ray phase-contrast computed tomography (PC-CT) has been shown to provide improved soft-tissue contrast at a resolution formerly restricted to histopathology, at low doses. This study aimed at assessing ex-vivo the potential use of PC-CT for visualizing the effects of neoadjuvant chemotherapy on breast carcinoma.

MATERIALS AND METHODS

The analysis was performed on two ex-vivo formalin-fixed mastectomy samples containing an invasive carcinoma removed from two patients treated with neoadjuvant chemotherapy. Images were matched with corresponding histological slices. The visibility of typical post-therapeutic tissue changes was assessed and compared to results obtained with conventional clinical imaging modalities.

RESULTS

PC-CT depicted the different tissue types with an excellent correlation to histopathology. Post-therapeutic tissue changes were correctly visualized and the residual tumor mass could be detected. PC-CT outperformed clinical imaging modalities in the detection of chemotherapy-induced tissue alterations including post-therapeutic tumor size.

CONCLUSIONS

PC-CT might become a unique diagnostic tool in the prediction of tumor response to neoadjuvant chemotherapy. PC-CT might be used to assist during histopathological diagnosis, offering a high-resolution and high-contrast virtual histological tool for the accurate delineation of tumor boundaries.

摘要

目的

新辅助化疗是晚期乳腺癌的先进治疗方法。准确显示治疗后肿瘤大小具有高度的预后相关性。X射线相衬计算机断层扫描（PC-CT）已被证明能够在低剂量下，以以前仅组织病理学所具备的分辨率提供更好的软组织对比度。本研究旨在评估PC-CT在体外对可视化新辅助化疗对乳腺癌的疗效的潜在用途。

材料与方法

对两个来自接受新辅助化疗的患者的离体福尔马林固定乳房切除样本进行分析，样本包含浸润性癌。将图像与相应的组织学切片进行匹配。评估典型治疗后组织变化的可见性，并与传统临床成像方式获得的结果进行比较。

结果

PC-CT描绘的不同组织类型与组织病理学具有极好的相关性。治疗后组织变化得到正确显示，并且可以检测到残留肿瘤块。在检测化疗引起的组织改变（包括治疗后肿瘤大小）方面，PC-CT优于临床成像方式。

结论

PC-CT可能成为预测肿瘤对新辅助化疗反应的独特诊断工具。PC-CT可用于在组织病理学诊断过程中提供辅助，为准确描绘肿瘤边界提供高分辨率和高对比度的虚拟组织学工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/4c366c9ca3a0/pone.0158306.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/120db1b32610/pone.0158306.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/ce667f37b423/pone.0158306.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/00e8657ca3e1/pone.0158306.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/2dbf1c74161c/pone.0158306.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/555cc77bc6de/pone.0158306.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/1fc32ba3ca11/pone.0158306.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/a6b74fd043ea/pone.0158306.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/4c366c9ca3a0/pone.0158306.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/120db1b32610/pone.0158306.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/ce667f37b423/pone.0158306.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/00e8657ca3e1/pone.0158306.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/2dbf1c74161c/pone.0158306.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/555cc77bc6de/pone.0158306.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/1fc32ba3ca11/pone.0158306.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/a6b74fd043ea/pone.0158306.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/4928822/4c366c9ca3a0/pone.0158306.g008.jpg

相似文献

1
Detection of Post-Therapeutic Effects in Breast Carcinoma Using Hard X-Ray Index of Refraction Computed Tomography - A Feasibility Study.使用硬X射线折射率计算机断层扫描检测乳腺癌的治疗后效果——一项可行性研究
PLoS One. 2016 Jun 30;11(6):e0158306. doi: 10.1371/journal.pone.0158306. eCollection 2016.
2
Evaluation of phase-contrast CT of breast tissue at conventional X-ray sources - presentation of selected findings.常规 X 射线源下乳腺组织的相位对比 CT 评估 - 部分发现的呈现。
Z Med Phys. 2013 Sep;23(3):212-21. doi: 10.1016/j.zemedi.2013.02.005. Epub 2013 Mar 11.
3
Visualizing typical features of breast fibroadenomas using phase-contrast CT: an ex-vivo study.使用相位对比CT可视化乳腺纤维腺瘤的典型特征：一项离体研究。
PLoS One. 2014 May 13;9(5):e97101. doi: 10.1371/journal.pone.0097101. eCollection 2014.
4
CT findings of breast cancer with clinically complete response following neoadjuvant chemotherapy--histological correlation.新辅助化疗后临床完全缓解的乳腺癌的CT表现——组织学相关性
Oncol Rep. 2003 Sep-Oct;10(5):1411-5.
5
X-ray phase-contrast tomosynthesis for improved breast tissue discrimination.X 射线相衬断层合成术提高乳腺组织的分辨能力。
Eur J Radiol. 2014 Mar;83(3):531-6. doi: 10.1016/j.ejrad.2013.12.005. Epub 2013 Dec 12.
6
Utility of MRI and PET/CT after neoadjuvant chemotherapy in breast cancer patients: correlation with pathological response grading system based on tumor cellularity.新辅助化疗后MRI和PET/CT在乳腺癌患者中的应用：与基于肿瘤细胞密度的病理反应分级系统的相关性
Acta Radiol. 2014 May;55(4):399-408. doi: 10.1177/0284185113498720. Epub 2013 Aug 20.
7
Thin-section CT evaluation and pathologic correlation of therapeutic effect of neoadjuvant chemotherapy for axillary lymph nodes of clinically node-positive breast cancer patients.临床淋巴结阳性乳腺癌患者腋窝淋巴结新辅助化疗疗效的薄层CT评估及病理对照
Oncol Rep. 2003 Jul-Aug;10(4):985-9.
8
Early metabolic response to neoadjuvant letrozole, measured by FDG PET/CT, is correlated with a decrease in the Ki67 labeling index in patients with hormone receptor-positive primary breast cancer: a pilot study.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）检测新辅助来曲唑治疗后早期代谢反应与激素受体阳性原发性乳腺癌患者 Ki67 标记指数降低相关：一项初步研究。
Breast Cancer. 2011 Oct;18(4):299-308. doi: 10.1007/s12282-010-0212-y. Epub 2010 Jul 9.
9
Neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with systemic chemotherapy in patients with breast cancer.新辅助间质高剂量率（HDR）近距离放射治疗联合全身化疗用于乳腺癌患者。
Strahlenther Onkol. 2006 Jan;182(1):22-9. doi: 10.1007/s00066-006-1454-7.
10
Treatment Response Evaluation of Breast Cancer after Neoadjuvant Chemotherapy and Usefulness of the Imaging Parameters of MRI and PET/CT.新辅助化疗后乳腺癌的治疗反应评估及MRI和PET/CT成像参数的应用价值
J Korean Med Sci. 2015 Jun;30(6):808-15. doi: 10.3346/jkms.2015.30.6.808. Epub 2015 May 13.

引用本文的文献

1
Quantitative X-ray phase contrast computed tomography with grating interferometry : Biomedical applications of quantitative X-ray grating-based phase contrast computed tomography.基于光栅的定量 X 射线相衬计算机断层成像术：定量 X 射线光栅相衬计算机断层成像术的生物医学应用。
Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4171-4188. doi: 10.1007/s00259-021-05259-6. Epub 2021 Apr 13.
2
Review of quantitative multiscale imaging of breast cancer.乳腺癌定量多尺度成像综述。
J Med Imaging (Bellingham). 2018 Jan;5(1):010901. doi: 10.1117/1.JMI.5.1.010901. Epub 2018 Jan 22.

本文引用的文献

1
A single-image method for x-ray refractive index CT.一种用于X射线折射率CT的单图像方法。
Phys Med Biol. 2015 May 7;60(9):3433-40. doi: 10.1088/0031-9155/60/9/3433. Epub 2015 Apr 9.
2
Role of imaging in neoadjuvant therapy for breast cancer.影像学在乳腺癌新辅助治疗中的作用。
Ann Surg Oncol. 2015 May;22(5):1416-24. doi: 10.1245/s10434-015-4403-9. Epub 2015 Mar 2.
3
Radiation dose in breast CT imaging with monochromatic x-rays: simulation study of the influence of energy, composition and thickness.单色 X 射线乳腺 CT 成像中的辐射剂量：能量、组成和厚度影响的模拟研究。
Phys Med Biol. 2014 May 7;59(9):2199-217. doi: 10.1088/0031-9155/59/9/2199. Epub 2014 Apr 8.
4
Tomographic reconstruction of the refractive index with hard X-rays: an efficient method based on the gradient vector-field approach.利用硬X射线进行折射率的断层重建：一种基于梯度向量场方法的有效方法。
Opt Express. 2014 Mar 10;22(5):5216-27. doi: 10.1364/OE.22.005216.
5
X-ray phase-contrast imaging: from pre-clinical applications towards clinics.X 射线相衬成像：从临床前应用走向临床。
Phys Med Biol. 2013 Jan 7;58(1):R1-35. doi: 10.1088/0031-9155/58/1/R1. Epub 2012 Dec 10.
6
High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers.高分辨率、低剂量的相衬 X 射线断层扫描术用于人类乳腺癌的 3D 诊断。
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18290-4. doi: 10.1073/pnas.1204460109. Epub 2012 Oct 22.
7
Assessment of grating-based X-ray phase-contrast CT for differentiation of invasive ductal carcinoma and ductal carcinoma in situ in an experimental ex vivo set-up.基于光栅的 X 射线相衬 CT 在实验离体设置中鉴别浸润性导管癌和导管原位癌的评估。
Eur Radiol. 2013 Feb;23(2):381-7. doi: 10.1007/s00330-012-2592-1. Epub 2012 Aug 31.
8
High-resolution breast tomography at high energy: a feasibility study of phase contrast imaging on a whole breast.高能下高分辨率乳腺断层成像：全乳相位衬度成像的可行性研究。
Phys Med Biol. 2012 May 21;57(10):2931-42. doi: 10.1088/0031-9155/57/10/2931. Epub 2012 Apr 20.
9
Is breast specimen shrinkage really a problem in breast-conserving surgery?保乳手术中乳腺标本的皱缩真的是个问题吗？
J Clin Pathol. 2012 Mar;65(3):224-7. doi: 10.1136/jclinpath-2011-200392. Epub 2011 Nov 2.
10
Functional magnetic resonance: biomarkers of response in breast cancer.功能磁共振：乳腺癌反应的生物标志物。
Breast Cancer Res. 2011 Feb 23;13(1):204. doi: 10.1186/bcr2815.