Tsujikawa Kenji, Yamamuro Tadashi, Kuwayama Kenji, Kanamori Tatsuyuki, Iwata Yuko T, Miyamoto Kazuna, Kasuya Fumiyo, Inoue Hiroyuki
National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.
Biochemical Toxicology Laboratory, Faculty of Pharmaceutical Sciences, Kobegakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8586, Japan.
J Forensic Sci. 2016 Sep;61(5):1208-14. doi: 10.1111/1556-4029.13122. Epub 2016 Jun 30.
This is the first report on development of a library search-based screening system for 3,4-methylenedioxymethamphetamine (MDMA) in ecstasy tablets using a portable near-infrared (NIR) spectrometer. The spectrum library consisted of spectra originating from standard substances as well as mixtures of MDMA hydrochloride (MDMA-HCl) and diluents. The raw NIR spectra were mathematically pretreated, and then, a library search was performed using correlation coefficient. To enhance the discrimination ability, the wavelength used for the library search was limited. Mixtures of MDMA-HCl and diluents were used to decide criteria to judge MDMA-positive or MDMA-negative. Confiscated MDMA tablets and medicinal tablets were used for performance check of the criteria. Twenty-two of 27 MDMA tablets were truly judged as MDMA-positive. Five false-negative results may be caused by compounds not included in the library. No false-positive results were obtained for medicinal tablets. This system will be a useful tool for on-site screening of MDMA tablets.
这是关于使用便携式近红外（NIR）光谱仪开发基于库搜索的摇头丸片剂中3,4-亚甲基二氧甲基苯丙胺（MDMA）筛选系统的首份报告。光谱库由源自标准物质以及盐酸MDMA（MDMA-HCl）与稀释剂混合物的光谱组成。对原始近红外光谱进行数学预处理，然后使用相关系数进行库搜索。为提高鉴别能力，限制了用于库搜索的波长。使用MDMA-HCl与稀释剂的混合物来确定判断MDMA阳性或阴性的标准。没收的MDMA片剂和药片片剂用于该标准的性能检查。27片MDMA片剂中有22片被正确判断为MDMA阳性。5例假阴性结果可能是由库中未包含的化合物导致的。药片片剂未获得假阳性结果。该系统将成为现场筛选MDMA片剂的有用工具。
