非法摇头丸片剂分析：对急诊科临床管理的启示
Analysis of illicit ecstasy tablets: implications for clinical management in the accident and emergency department.
作者信息
Sherlock K, Wolff K, Hay A W, Conner M
机构信息
Ethnicity and Health Unit, Faculty of Health, University of Central Lancashire, Preston.
出版信息
J Accid Emerg Med. 1999 May;16(3):194-7. doi: 10.1136/emj.16.3.194.
Abstract
OBJECTIVE
To examine the composition of illicitly manufactured "ecstasy" tablets sold on the UK drugs market.
METHODS
Analysis by gas chromatography of 25 illicit ecstasy tablets handed in under amnesty to Leeds Addiction Unit.
RESULTS
Illicitly manufactured ecstasy tablets contain a range of ingredients, of widely differing concentrations, and even tablets with the same brand name have variable concentrations of active ingredients. Concentrations of 3,4-methylenedioxymethamphetamine (MDMA) more popularly known as ecstasy, varied 70-fold between tablets. Nine tablets contained neither MDMA nor related analogues.
CONCLUSIONS
These results have implications for emergency workers attending to those who have become casualties of the drug ecstasy. Those claiming to have ingested ecstasy may actually have taken other agents that require different clinical management.
摘要
目的
检测在英国毒品市场上销售的非法制造的“摇头丸”片剂的成分。
方法
对根据大赦令上交至利兹成瘾科的25片非法摇头丸进行气相色谱分析。
结果
非法制造的摇头丸片剂含有一系列成分，浓度差异很大，甚至同一品牌的片剂其活性成分浓度也各不相同。俗称摇头丸的3,4-亚甲基二氧甲基苯丙胺（MDMA）的浓度在不同片剂之间相差70倍。9片药片中既不含MDMA也不含相关类似物。
结论
这些结果对救治摇头丸中毒人员的急救人员具有启示意义。那些声称摄入摇头丸的人实际上可能服用了其他需要不同临床处理的药物。
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本文引用的文献
1
Enantioselective determination of 3,4-methylene-dioxymethamphetamine and two of its metabolites in human urine by cyclodextrin-modified capillary zone electrophoresis.通过环糊精修饰的毛细管区带电泳对人尿中3,4-亚甲基二氧甲基苯丙胺及其两种代谢物进行对映体选择性测定。
Electrophoresis. 1997 Jun;18(6):1035-43. doi: 10.1002/elps.1150180628.
2
Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS.采用高效液相色谱-二极管阵列检测法（HPLC-DAD）和气相色谱-质谱联用法（GC-MS）分析血浆和尿液中的3,4-亚甲基二氧甲基苯丙胺（摇头丸，MDMA）及其代谢产物。
J Anal Toxicol. 1996 Oct;20(6):432-40. doi: 10.1093/jat/20.6.432.
3
Alcohol and drug use in UK university students.英国大学生的酒精和药物使用情况。
Lancet. 1996 Oct 5;348(9032):922-5. doi: 10.1016/s0140-6736(96)03410-1.
4
Drinking, smoking, and illicit drug use among 15 and 16 year olds in the United Kingdom.英国15至16岁青少年的饮酒、吸烟及非法药物使用情况。
BMJ. 1996 Aug 17;313(7054):394-7. doi: 10.1136/bmj.313.7054.394.
5
Pathology of deaths associated with "ecstasy" and "eve" misuse.与滥用“摇头丸”和“伊芙”相关的死亡病理学。
J Clin Pathol. 1996 Feb;49(2):149-53. doi: 10.1136/jcp.49.2.149.
6
Pharmacokinetics and analgesic effects of i.m. and oral ketamine.
Br J Anaesth. 1981 Aug;53(8):805-10. doi: 10.1093/bja/53.8.805.
7
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
J Pharm Sci. 1982 May;71(5):539-42. doi: 10.1002/jps.2600710516.
8
Ketamine as an induction agent in anaesthetics.氯胺酮作为麻醉诱导剂。
Lancet. 1970 Jun 27;1(7661):1370-1. doi: 10.1016/s0140-6736(70)91273-0.
9
Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy").3,4－亚甲基二氧甲基苯丙胺（“摇头丸”）的毒性及致死情况。
Lancet. 1992 Aug 15;340(8816):384-7. doi: 10.1016/0140-6736(92)91469-o.
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