Wens Inez, Dalgas Ulrik, Vandenabeele Frank, Verboven Kenneth, Hansen Dominique, Deckx Nathalie, Cools Nathalie, Eijnde Bert O
From the REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium (IW, FV, KV, DH, BOE); Section of Sport Science, Department of Public Health, Aarhus University, Aarhus, Denmark (UD); and Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp University Hospital, Edegem, Belgium (ND, NC).
Am J Phys Med Rehabil. 2017 Mar;96(3):161-166. doi: 10.1097/PHM.0000000000000563.
The prevalence of impaired glucose tolerance (IGT) is higher in persons with multiple sclerosis (MS) compared to healthy controls, indicating metabolic deficits that may increase comorbidity. In other populations, IGT can, at least partly, be reversed by intense physical exercise, but this is never investigated before in MS.
To investigate the effect of high intensity aerobic and resistance training on glucose tolerance and skeletal muscle GLUT4 content in MS.
Thirty-four persons with MS (aged 45 ± 3 years, EDSS 2.5 ± 1.07) were randomized into three groups, including a (1) sedentary control group (SED, n = 11), (2) 12-week high intensity interval plus resistance training group (HITR, n = 12), or (3) 12-week high intensity continuous aerobic training plus resistance training group (HCTR, n = 11). Before and after 12 weeks, glucose tolerance and skeletal muscle GLUT4 content were determined by an oral glucose tolerance test and analysis of a m.vastus lateralis biopsy, respectively.
There were no significant changes for subjects of SED. From pre- to post-intervention, total area under the glucose curve (tAUC) decreased significantly in both HITR (-6.9 ± 6.2%) and HCTR (-11.0 ± 7.7%) (P < 0.05). Insulin tAUC decreased (-12.3 ± 14.7%) within HCTR and muscle GLUT4 content increased (+6.6 ± 4.5%) in HITR.
Twelve weeks of high intensity aerobic exercise in combination with resistance training improved glucose tolerance in persons with MS.
与健康对照组相比，多发性硬化症（MS）患者的糖耐量受损（IGT）患病率更高，这表明代谢缺陷可能会增加合并症的发生。在其他人群中，高强度体育锻炼至少可以部分逆转IGT，但此前从未在MS患者中进行过研究。
研究高强度有氧训练和抗阻训练对MS患者糖耐量和骨骼肌葡萄糖转运蛋白4（GLUT4）含量的影响。
34例MS患者（年龄45±3岁，扩展残疾状态量表评分2.5±1.07）被随机分为三组，包括：（1）久坐对照组（SED，n = 11）；（2）12周高强度间歇加抗阻训练组（HITR，n = 12）；或（3）12周高强度持续有氧训练加抗阻训练组（HCTR，n = 11）。在12周前后，分别通过口服葡萄糖耐量试验和股外侧肌活检分析来测定糖耐量和骨骼肌GLUT4含量。
SED组受试者无显著变化。从干预前到干预后，HITR组（-6.9±6.2%）和HCTR组（-11.0±7.7%）的葡萄糖曲线下总面积（tAUC）均显著下降（P<0.05）。HCTR组胰岛素tAUC下降（-12.3±14.7%），HITR组肌肉GLUT4含量增加（+6.6±4.5%）。
12周的高强度有氧运动结合抗阻训练可改善MS患者的糖耐量。
