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24周抗阻和耐力运动对多发性硬化症患者葡萄糖耐量的影响。

Impact of 24 Weeks of Resistance and Endurance Exercise on Glucose Tolerance in Persons with Multiple Sclerosis.

作者信息

Wens Inez, Hansen Dominique, Verboven Kenneth, Deckx Nathalie, Kosten Lauren, Stevens An L M, Cools Nathalie, Eijnde Bert O

机构信息

From the REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek (IW, DH, KV, LK, ALMS, BOE); and Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp University Hospital, Edegem, Belgium (ND, NC).

出版信息

Am J Phys Med Rehabil. 2015 Oct;94(10 Suppl 1):838-47. doi: 10.1097/PHM.0000000000000257.

Abstract

BACKGROUND

Recently, the authors reported an elevated prevalence of impaired glucose tolerance in individuals with multiple sclerosis (MS), compared with matched healthy controls, indicating metabolic defects that may increase comorbidity. MS also leads to a more inactive lifestyle, increasing the likelihood to develop fat accumulation, muscle wasting/weakness, and exercise intolerance. In other populations, these health complications can partly be reversed by physical exercise.

OBJECTIVE

The aim of this study was to determine the impact of a mild-to-moderate-intensity exercise program on glucose tolerance, ranging between normal and impaired, in persons with MS.

DESIGN

Persons with MS (mean expanded disability status scale, 3.3 ± 0.2; mean age, 48 ± 15 yrs) were randomized to an exercise group (n = 29) or a nonexercise control group (n = 15). Glucose tolerance, as well as muscle strength, exercise tolerance, and body composition to validate the applied exercise program, was determined in both groups at baseline and after 6, 12, and 24 wks of mild-to-moderate-intensity combined endurance and resistance training.

RESULTS

No effects on blood glucose and serum insulin were detected. However, 6 mos of exercise improved muscle strength, exercise tolerance, and lean tissue mass within the intervention group as compared with baseline. In the control group, no changes were detected.

CONCLUSION

Twenty-four weeks of mild-to-moderate-intensity combined endurance and resistance training was not able to improve glycemic control in this cohort of persons with MS. Future research is warranted to investigate the influence of higher exercise intensities on glucose tolerance, in an attempt to remediate metabolic deficits and to decrease the prevalence of comorbidities in MS.

摘要

背景

最近,作者报告称,与匹配的健康对照组相比,多发性硬化症(MS)患者糖耐量受损的患病率有所升高,这表明代谢缺陷可能会增加合并症的发生。MS还会导致生活方式更加缺乏活力,增加脂肪堆积、肌肉萎缩/无力和运动不耐受的发生可能性。在其他人群中,这些健康并发症可通过体育锻炼得到部分逆转。

目的

本研究的目的是确定轻度至中度强度的运动计划对MS患者糖耐量(范围在正常和受损之间)的影响。

设计

将MS患者(平均扩展残疾状态量表评分为3.3±0.2;平均年龄为48±15岁)随机分为运动组(n = 29)或非运动对照组(n = 15)。在基线以及进行6、12和24周的轻度至中度强度的耐力和阻力联合训练后,对两组患者的糖耐量以及肌肉力量、运动耐力和身体成分进行测定,以验证所应用的运动计划。

结果

未检测到对血糖和血清胰岛素的影响。然而,与基线相比,干预组进行6个月的运动后肌肉力量、运动耐力和瘦体重有所改善。在对照组中,未检测到变化。

结论

24周的轻度至中度强度的耐力和阻力联合训练未能改善该队列MS患者的血糖控制。有必要进行进一步研究,以调查更高运动强度对糖耐量的影响,试图纠正代谢缺陷并降低MS合并症的患病率。

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