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[大鼠可逆性深度全身低温]

[Reversible deep whole-body hypothermia in rats].

作者信息

Shcherbakov P V, Tel'pukhov V I, Khokhlov A V

出版信息

Biull Eksp Biol Med. 1989 May;107(5):543-5.

PMID:2736281
Abstract

The effect of deep hypothermia on the rat's organism was investigated without the use of hypercapnic hypoxia or administration of medicine. The possibility of resuscitation and rehabilitation of rats after deep hypothermia depending on different rate of heating have been also studied. It has been observed that the cardiac activity stopped at about 3 degrees C. We supposed that the extremely intensive heating and temperature rise of an organism were both limiting factors. We have discovered that the low intensity of heating was the next factor of limitation which was connected with the duration of clinical death. These experiments showed that the intensive cooling and heating (about 0.4 degrees C per min.) are the best for resuscitation and rehabilitation after deep hypothermia.

摘要

在不使用高碳酸血症性缺氧或给药的情况下,研究了深度低温对大鼠机体的影响。还研究了根据不同加热速率,大鼠在深度低温后复苏和恢复的可能性。据观察,心脏活动在约3摄氏度时停止。我们认为机体的极强烈加热和温度升高都是限制因素。我们发现低加热强度是与临床死亡持续时间相关的下一个限制因素。这些实验表明,强烈的冷却和加热(约每分钟0.4摄氏度)最有利于深度低温后的复苏和恢复。

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