[匹卡米隆对软脑膜动脉系统皮质血液供应及微循环的影响]
[Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system].
作者信息
Mirzoian R S, Gan'shina T S, Kosoĭ M Iu, Aleksandrin V V, Aleksandrin P N
出版信息
Biull Eksp Biol Med. 1989 May;107(5):581-2.
PMID:2736292
Abstract
Pikamilon was shown to increase blood supply in cerebral cortex in conscious rats and rabbits. The increase in blood flow has been revealed under intravenous, intraperitoneal and systemic administration of the drug. There is a pronounced dilatation of pial arterioles under pikamilon action while applied locally. Most dilation occurs in arterioles with the initial diameter of 10-20 microns. With the increase of pial arterioles diameter, dilatory effect of pikamilon, is reduced.
摘要
匹卡米隆已被证明可增加清醒大鼠和兔子大脑皮层的血液供应。在静脉内、腹腔内和全身给药该药物后，均发现血流量增加。局部应用匹卡米隆时，软脑膜小动脉会出现明显扩张。大多数扩张发生在初始直径为10 - 20微米的小动脉中。随着软脑膜小动脉直径的增加，匹卡米隆的扩张作用会减弱。
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