Yao Zhi-Gang, Liu Xiu-Mei, Qin Ye-Jun
a Department of Pathology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
b Department of Pathology , Qi Lu Children's Hospital of Shandong University , Jinan , China.
Fetal Pediatr Pathol. 2016;35(6):410-415. doi: 10.1080/15513815.2016.1191568. Epub 2016 Jun 30.
We describe two children with ganglioneuroma (GN) likely originating from incompletely resected neuroblastoma (NB) during infancy, stages 2A and 2B, who did not undergo postoperative adjuvant chemotherapies. Both NB tumors had no MYCN amplification, had TrKA but no TrkB expression, and by TUNEL had apoptosis. These findings may have contributed to spontaneous maturation of the residual primary NB and hence the favorable prognosis, which suggests surgery alone might be the sufficient initial therapy for low-risk patients.
我们描述了两名患有神经节神经瘤（GN）的儿童，其可能起源于婴儿期未完全切除的神经母细胞瘤（NB），分期为2A和2B期，且未接受术后辅助化疗。这两个NB肿瘤均无MYCN扩增，有TrKA表达但无TrkB表达，且通过TUNEL检测有凋亡现象。这些发现可能促成了残留原发性NB的自发成熟，从而带来良好的预后，这表明对于低风险患者，单纯手术可能是足够的初始治疗方法。
