[肺结核患者血清中可溶性T细胞免疫球蛋白黏蛋白分子3和白细胞介素-4水平升高及干扰素-γ水平降低]

[Increased serum levels of soluble T cell immunoglobulin mucin molecule 3 and IL-4 and decreased IFN-γ in patients with pulmonary tuberculosis].

作者信息

Zhang Jia, Zhang Fengbo, Li Qifeng, Zhao Yunjuan, Guo Nan, Li Fan, Xia Yu, Ding Jianbing

机构信息

First Affiliated Hospital, Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.

First Affiliated Hospital, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.

出版信息

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jul;32(7):968-71.

PMID:27363280

Abstract

Objective To detect the serum levels of soluble T cell immunoglobulin mucin molecule 3 (sTim-3), IFN-γ and IL-4 in patients with pulmonary tuberculosis. Methods Peripheral blood was collected from 48 patients with pulmonary tuberculosis and 20 healthy controls. The serum level of sTim-3 was detected by ELISA. The levels of IFN-γ and IL-4 were determined by cytokine bead array (CBA). The correlations between sTim-3, IFN-γ and IL-4 levels in sera of patients with pulmonary tuberculosis were analyzed by Pearson correlation test. Results Compared with the control group, the serum levels of sTim-3 and IL-4 increased significantly, while the level of IFN-γ decreased significantly. Pearson analysis showed that there was a negative correlation between sTim-3 and IFN-γ as well as between IFN-γ and IL-4 in patients with pulmonary tuberculosis, while sTim-3 and IL-4 were positively correlated. Conclusion The serum levels of sTim-3 and IL-4 increase, but IFN-γ decreases in the patients with pulmonary tuberculosis.

摘要

目的检测肺结核患者血清中可溶性T细胞免疫球蛋白黏蛋白分子3（sTim-3）、干扰素-γ（IFN-γ）及白细胞介素-4（IL-4）水平。方法收集48例肺结核患者及20例健康对照者的外周血。采用酶联免疫吸附测定（ELISA）法检测血清sTim-3水平。采用细胞因子微球阵列（CBA）法测定IFN-γ和IL-4水平。采用Pearson相关检验分析肺结核患者血清中sTim-3、IFN-γ和IL-4水平之间的相关性。结果与对照组相比，肺结核患者血清sTim-3和IL-4水平显著升高，而IFN-γ水平显著降低。Pearson分析显示，肺结核患者sTim-3与IFN-γ之间以及IFN-γ与IL-4之间呈负相关，而sTim-3与IL-4呈正相关。结论肺结核患者血清sTim-3和IL-4水平升高，但IFN-γ水平降低。