Yan Shunjie, Song Lingjie, Li Zhihong, Luan Shifang, Shi Hengchong, Xin Zhirong, Li Shenghai, Yang Yuming, Yin Jinghua
a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
b University of Chinese Academy of Sciences , Beijing , People's Republic of China.
J Biomater Sci Polym Ed. 2016 Oct;27(14):1397-412. doi: 10.1080/09205063.2016.1207491. Epub 2016 Jul 18.
The bacteria-repellent and bactericidal functionalities in a single system are generally need to be carefully optimized in order to obtain the highest antibacterial performance. In this study, the controlled SI-PIMP strategy was developed for creating hierarchical polymer brushes possessing the bacteria-repellent and bactericidal functionalities. To obtain a bactericidal surface with minimal interference to its nonfouling property, optimization studies were conducted by facilely tailoring the surface density of the quaternary ammonium compound moieties through control over the monomer concentration. An optimal hierarchical polymer coating showed potent protein and bacteria repellence as well as certain bactericidal property. The longlasting antibacterial performance was also achieved due to the good balance between the dual functionalities. The tenability of the hierarchical polymer coating is applicable to surface chemistries for biosensors, molecular imaging, and biomedical applications.
为了获得最高的抗菌性能，通常需要在单一系统中仔细优化抗菌和杀菌功能。在本研究中，开发了可控的表面引发原子转移自由基聚合（SI-PIMP）策略，以制备具有抗菌和杀菌功能的分级聚合物刷。为了获得对其防污性能干扰最小的杀菌表面，通过控制单体浓度来轻松调整季铵化合物部分的表面密度，进行了优化研究。一种最佳的分级聚合物涂层表现出强大的蛋白质和细菌排斥性以及一定的杀菌性能。由于这两种功能之间的良好平衡，还实现了持久的抗菌性能。分级聚合物涂层的可调节性适用于生物传感器、分子成像和生物医学应用的表面化学。
