Yan Shunjie, Song Lingjie, Luan Shifang, Xin Zhirong, Du Shanshan, Shi Hengchong, Yuan Shuaishuai, Yang Yuming, Yin Jinghua
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Colloids Surf B Biointerfaces. 2017 Jan 1;149:260-270. doi: 10.1016/j.colsurfb.2016.08.012. Epub 2016 Aug 12.
Bacterial infections are problematic in many healthcare-associated devices. Antibacterial surfaces integrating the strength of bacteria repellent and bactericidal functions exhibit an encouraging efficacy in tackling this problem. Herein, a hierarchical dual-function antibacterial polymer brush coating that integrates an antifouling bottom layer with a bactericidal top layer is facilely constructed via living photograft polymerization. Excellent resistance to bacterial attachment is correlated with the antifouling components, and good bactericidal activity is afforded by the bactericidal components, and therefore the hierarchical coating shows an excellent long-term antibacterial capability. In addition, due to the presence of the hydrophilic background layer, the hierarchical surface has the greatly improved biocompatibility, as shown by the suppression of platelet adhesion and activation, the inhibition of erythrocyte adhesion and damage, and low toxicity against mammalian cells. The hierarchical polymer brush system provides the basis for the development of long-term antibacterial and biocompatible surfaces.
细菌感染在许多医疗相关设备中都是个问题。兼具驱菌和杀菌功能的抗菌表面在解决这一问题方面展现出了令人鼓舞的效果。在此，通过活性光接枝聚合简便地构建了一种分层双功能抗菌聚合物刷涂层，该涂层将防污底层与杀菌顶层结合在一起。对细菌附着的优异抗性与防污成分相关，杀菌成分则赋予了良好的杀菌活性，因此这种分层涂层显示出优异的长期抗菌能力。此外，由于亲水性背景层的存在，分层表面具有大大改善的生物相容性，这表现为血小板黏附与活化的抑制、红细胞黏附与损伤的抑制以及对哺乳动物细胞的低毒性。这种分层聚合物刷系统为长期抗菌且生物相容表面的开发提供了基础。
