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(E)-N'-(取代亚苄基)-2-(2-氟苄基)-5-乙基-2H-1,2,3-三唑-4-碳酰肼的合成、表征及抗菌活性评价

Synthesis, characterization and evaluation of antibacterial activity of (E)-N'-(substituted benzylidene)-2-(2-fluorobenzyl)-5-ethyl-2H-1,2,3-triazole-4-carbohydrazides.

作者信息

Reddy P V B, Kamala Prasad V, Manjunath G, Venkata Ramana P

机构信息

Department of Chemistry, Sri Krishnadevaraya University, 515 003, Ananthapuramu, Andhra Pradesh, India.

Denisco Chemicals Pvt. Ltd., 500 055, Hyderabad, Telangana State, India.

出版信息

Ann Pharm Fr. 2016 Sep;74(5):350-7. doi: 10.1016/j.pharma.2016.05.002. Epub 2016 Jun 27.

Abstract

Triazoles and their derivatives are important precursors in the pharmacological field due to their broad diversity of medicinal and biological deed. In this article, the exploration is to put an effort to produce some novel biologically active triazole 4-carbohydrazide derivatives. The structures of the newly synthesized compounds were characterized and confirmed by spectral data and were screened for anti-bacterial activity. Compounds 5(d-i), 5l and 5m were observed to possess potent anti-microbial activity.

摘要

由于三唑及其衍生物具有广泛多样的药用和生物学特性,它们在药理学领域是重要的前体。在本文中,我们致力于合成一些新型的具有生物活性的三唑-4-碳酰肼衍生物。新合成化合物的结构通过光谱数据进行了表征和确认,并对其抗菌活性进行了筛选。观察到化合物5(d-i)、5l和5m具有强效抗菌活性。

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