Department of Dermatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.
Rev Endocr Metab Disord. 2016 Sep;17(3):449-457. doi: 10.1007/s11154-016-9371-2.
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin. In addition, their effects on keratinocytes, melanocytes, sebocytes, inflammatory and immunological cells, and skin stem cells produce inflammatory and allergic skin diseases, chloracne, disorders of skin pigmentation, skin cancer, and skin aging. Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway. Further studies on EDCs and skin diseases are necessary to elucidate these mechanisms.
内分泌干扰化学物质（EDCs）是具有通过与激素受体直接或间接相互作用而破坏激素产生和作用的能力的外源性化合物，从而充当激动剂或拮抗剂。人类健康在个体职业或饮食和环境暴露于 EDC 后受到影响。另一方面，皮肤是人体最大的器官之一，其主要功能是保护身体免受有害物质的侵害。EDCs 扰乱内分泌系统，对人类皮肤也具有致癌性、免疫毒性和肝毒性。此外，它们对角质形成细胞、黑素细胞、皮脂细胞、炎症和免疫细胞以及皮肤干细胞的影响会产生炎症性和过敏性皮肤疾病、氯痤疮、皮肤色素沉着紊乱、皮肤癌和皮肤老化。EDCs 诱导这些皮肤疾病的机制很复杂，涉及内源性激素的干扰，最重要的是芳基烃受体信号通路的激活。需要进一步研究 EDC 和皮肤疾病，以阐明这些机制。
