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[Methotrexate].

作者信息

Rau R

机构信息

, Irisweg 5, 40489, Düsseldorf, Deutschland.

出版信息

Z Rheumatol. 2016 Aug;75(6):599-603. doi: 10.1007/s00393-016-0118-y.

DOI:10.1007/s00393-016-0118-y
PMID:27365027
Abstract
摘要

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[Methotrexate].[甲氨蝶呤]
Z Rheumatol. 2016 Aug;75(6):599-603. doi: 10.1007/s00393-016-0118-y.
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[Glucocorticoids].[糖皮质激素]
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A review of methotrexate-associated hepatotoxicity.甲氨蝶呤相关肝毒性的综述。
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Monitoring methotrexate hepatic toxicity in rheumatoid arthritis: is it time to update the guidelines?监测类风湿关节炎中甲氨蝶呤的肝毒性:是时候更新指南了吗?
J Rheumatol. 2002 Aug;29(8):1586-9.
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Complications with low dose methotrexate in rheumatoid arthritis.类风湿关节炎中低剂量甲氨蝶呤的并发症
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7
Is there still a role for traditional disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis?传统抗风湿病情改善药(DMARDs)在类风湿关节炎治疗中是否仍有作用?
Curr Opin Rheumatol. 2003 May;15(3):185-92. doi: 10.1097/00002281-200305000-00003.
8
Combination therapy for rheumatoid arthritis with methotrexate and cyclosporine.
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Not yet time to change the guidelines for monitoring methotrexate liver toxicity: they have served us well.现在还不是时候改变甲氨蝶呤肝毒性监测指南:它们一直对我们很有用。
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本文引用的文献

1
Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial.托珠单抗治疗早期进展性类风湿关节炎:FUNCTION随机对照试验
Ann Rheum Dis. 2016 Jun;75(6):1081-91. doi: 10.1136/annrheumdis-2015-207628. Epub 2015 Oct 28.
2
The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.在未使用甲氨蝶呤且预后因素较差的早期类风湿性关节炎患者中开展的第一项关于赛妥珠单抗聚乙二醇化修饰物的双盲、随机、平行组研究——C-OPERA研究,显示出对影像学进展的抑制作用。
Ann Rheum Dis. 2016 Jan;75(1):75-83. doi: 10.1136/annrheumdis-2015-207511. Epub 2015 Jul 2.
3
Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period.
评估阿巴西普在早期类风湿关节炎中诱导无药缓解的效果:3b期多中心随机活性对照AVERT研究(为期24个月,其中12个月为双盲治疗期)的结果
Ann Rheum Dis. 2015 Jan;74(1):19-26. doi: 10.1136/annrheumdis-2014-206106. Epub 2014 Nov 3.
4
Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial.甲氨蝶呤剂量递增联合阿达木单抗的疗效与安全性:随机对照CONCERTO试验
Ann Rheum Dis. 2015 Jun;74(6):1037-44. doi: 10.1136/annrheumdis-2013-204769. Epub 2014 Feb 18.
5
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.利妥昔单抗联合甲氨蝶呤治疗早期活动性类风湿关节炎的疗效:IMAGE 试验。
Ann Rheum Dis. 2011 Jan;70(1):39-46. doi: 10.1136/ard.2010.137703. Epub 2010 Oct 11.
6
Antagonist for pteroylglutamic acid.蝶酰谷氨酸拮抗剂。
J Am Chem Soc. 1947 Oct;69(10):2567. doi: 10.1021/ja01202a519.
7
Two-year clinical and radiographic results with combination etanercept-methotrexate therapy versus monotherapy in early rheumatoid arthritis: a two-year, double-blind, randomized study.依那西普联合甲氨蝶呤疗法与单一疗法治疗早期类风湿关节炎的两年临床和影像学结果:一项为期两年的双盲随机研究
Arthritis Rheum. 2010 Mar;62(3):674-82. doi: 10.1002/art.27268.
8
Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as first-line therapy for early-onset rheumatoid arthritis.戈利木单抗,一种人抗肿瘤坏死因子α单克隆抗体,在未使用甲氨蝶呤的活动性类风湿关节炎患者中每四周皮下注射一次:一项戈利木单抗在甲氨蝶呤之前作为早发性类风湿关节炎一线治疗的III期、多中心、随机、双盲、安慰剂对照研究的24周结果。
Arthritis Rheum. 2009 Aug;60(8):2272-83. doi: 10.1002/art.24638.
9
Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial.聚乙二醇化赛妥珠单抗联合甲氨蝶呤治疗活动性类风湿关节炎的疗效和安全性:RAPID 2研究。一项随机对照试验。
Ann Rheum Dis. 2009 Jun;68(6):797-804. doi: 10.1136/ard.2008.101659. Epub 2008 Nov 17.
10
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.叶酸拮抗剂4-氨基蝶酰谷氨酸诱导儿童急性白血病的暂时缓解。
N Engl J Med. 1948 Jun 3;238(23):787-93. doi: 10.1056/NEJM194806032382301.