Pour P M, Kazakoff K
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68105-1065.
Cancer Lett. 1989 Jul 1;46(1):57-62. doi: 10.1016/0304-3835(89)90215-2.
Secretin (SEC) given s.c. to hamsters at a dose of 100 clinical units/kg body weight by 6 injections each 30 min apart, inhibited induction of pancreatic cancer when it was given prior to or simultaneously with a single dose of N-nitrosobis(2-oxopropyl)amine (BOP), but was ineffective in modifying tumor incidence when it was administered after BOP. The incidence of gall bladder and common bile tumors were not influenced, regardless of the time of SEC injections, implying that the inhibitory effect of this secretagogue is pancreas specific. However, a treatment schedule in which BOP and SEC were given weekly for 20 weeks did not alter the incidence of pancreatic tumors.
以100临床单位/千克体重的剂量给仓鼠皮下注射促胰液素（SEC），每隔30分钟注射1次，共注射6次。当在单次剂量的N-亚硝基双（2-氧代丙基）胺（BOP）之前或同时给予促胰液素时，可抑制胰腺癌的诱发，但在BOP给药后给予促胰液素时，对改变肿瘤发生率无效。无论促胰液素注射时间如何，胆囊和胆总管肿瘤的发生率均不受影响，这意味着这种促分泌素的抑制作用是胰腺特异性的。然而，BOP和SEC每周给药1次，共给药20周的治疗方案并未改变胰腺肿瘤的发生率。
