Howatson A G, Carter D C
J Natl Cancer Inst. 1987 Jan;78(1):101-5. doi: 10.1093/jnci/78.1.101.
The effect of exogenous secretin on pancreatic carcinogenesis in WO strain hamsters has been examined in the nitrosamine-ductular adenocarcinoma model. Secretin, 20 clinical U/kg, stimulated a maximal secretory response of pancreatic juice and bicarbonate when given iv. The same dose given sc for 6 weeks had no significant effect on pancreatic wet weight and DNA or RNA contents. However, when given to animals receiving N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4] (5 mg/kg), it reduced the latency and increased the induction rate of tumor development when compared with the carcinogen given alone to animals (secretin + BOP, 15 of 17 animals with tumors; BOP alone, 4 of 13 with tumors at 15 wk; P less than .002). These effects are consistent with secretin acting as a cocarcinogen in this model of pancreatic carcinogenesis.
在亚硝胺-小导管腺癌模型中，研究了外源性促胰液素对WO品系仓鼠胰腺癌发生的影响。静脉注射20临床单位/千克的促胰液素可刺激胰液和碳酸氢盐产生最大分泌反应。皮下注射相同剂量6周对胰腺湿重、DNA或RNA含量无显著影响。然而，当给予接受N-亚硝基双(2-氧代丙基)胺(BOP)，CAS: 60599-38-4的动物时，与单独给予致癌物的动物相比，它缩短了肿瘤发生的潜伏期并提高了诱导率(促胰液素+BOP组，17只动物中有15只发生肿瘤；单独BOP组，15周时13只中有4只发生肿瘤；P<0.002)。这些效应与促胰液素在该胰腺癌发生模型中作为一种促癌物的作用一致。
