使用胶囊内镜对不可切除的局部晚期胰腺癌进行放化疗后立即进行前瞻性小肠黏膜评估：病例系列研究

Prospective small bowel mucosal assessment immediately after chemoradiotherapy of unresectable locally advanced pancreatic cancer using capsule endoscopy: a case series.

作者信息

Yamashina Takeshi, Takada Ryoji, Uedo Noriya, Akasaka Tomofumi, Hanaoka Noboru, Takeuchi Yoji, Higashino Koji, Ioka Tatsuya, Ishihara Ryu, Teshima Teruki, Nishiyama Kinji, Iishi Hiroyasu

机构信息

Gastrointestinal Oncology (Takeshi Yamashina, Noriya Uedo, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Ruy Ishihara, Hiroyasu Iishi), Osaka, Japan; Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital (Takeshi Yamashina), Osaka, Japan.

Department of Pancreatic Oncology (Ryoji Takeda), Osaka, Japan.

出版信息

Ann Gastroenterol. 2016 Jul-Sep;29(3):386-8. doi: 10.20524/aog.2016.0063. Epub 2016 Feb 15.

DOI:10.20524/aog.2016.0063

PMID:27366048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4923833/

Abstract

In this case series, three consecutive patients with unresectable locally advanced pancreatic cancer (ULAPC) underwent capsule endoscopy (CE) before and after chemoradiotherapy (CRT) to evaluate duodenal and jejunal mucosa, and to examine the relationship between CE findings and dose distribution. CE after CRT showed duodenitis and proximal jejunitis in all three patients. The most inflamed region was the third part of the duodenum, and in dose distribution, this was the closest region to the center of irradiation. This case series shows that CE can safely diagnose acute duodenitis and proximal jejunitis caused by CRT for ULAPC, and that dose distribution is possible to predict the degree of duodenal and jejunal mucosal injuries.

摘要

在这个病例系列中，三名连续的不可切除局部晚期胰腺癌（ULAPC）患者在放化疗（CRT）前后接受了胶囊内镜检查（CE），以评估十二指肠和空肠黏膜，并检查CE结果与剂量分布之间的关系。CRT后的CE显示所有三名患者均有十二指肠炎和近端空肠炎。炎症最严重的区域是十二指肠第三部分，在剂量分布上，这是最接近照射中心的区域。这个病例系列表明，CE可以安全地诊断由CRT治疗ULAPC引起的急性十二指肠炎和近端空肠炎，并且剂量分布有可能预测十二指肠和空肠黏膜损伤的程度。