Wang Ji-Wei, Sun Li, Ding Ning, Li Jiang, Gong Xiao-Huan, Chen Xue-Fen, Yu Dong-Hui, Luo Zheng-Nian, Yuan Zheng-Ping, Yu Jin-Ming
School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, People's Republic of China.
School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, People's Republic of China; Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu Province, People's Republic of China.
Patient Prefer Adherence. 2016 Jun 14;10:1071-7. doi: 10.2147/PPA.S100873. eCollection 2016.
Cancer survivors with certain comorbidities had lower quality of life (QOL). This study was performed to investigate the prevalence of comorbidities and the association between comorbidities and the QOL among Chinese colorectal cancer survivors (CCS).
A cross-sectional study was conducted among 1,398 CCS between April and July 2013 in Shanghai, People's Republic of China. All the participants were asked to complete a simplified Chinese version of the European Organization for Research and Treatment quality of life version 3 questionnaire and questions on sociodemographic characteristics and comorbidities. In order to mitigate the bias caused by confounding factors, multiple linear regression models were employed to calculate the adjusted means of QOL scores.
The proportion of participants without any comorbidity was only 20.2%. The CCS with comorbidities except hypertension scored significantly lower on the European Organization for Research and Treatment quality of life version 3 questionnaire global health and functioning scales and Functional Assessment of Cancer Therapy-General scales but higher on the European Organization for Research and Treatment quality of life version 3 questionnaire symptom scores, indicating that they had poorer QOL, particularly for cardiovascular, respiratory, digestive, and musculoskeletal diseases.
There exists a significant association between comorbidities and QOL among Chinese CCS, and participants with comorbidities generally reported lower QOL scores. These findings suggested comprehensive care for CCS.
患有某些合并症的癌症幸存者生活质量（QOL）较低。本研究旨在调查中国结直肠癌幸存者（CCS）中合并症的患病率以及合并症与生活质量之间的关联。
2013年4月至7月间，在中国上海对1398名CCS进行了一项横断面研究。所有参与者均被要求完成欧洲癌症研究与治疗组织生活质量问卷第3版的简体中文版，以及关于社会人口学特征和合并症的问题。为了减轻混杂因素导致的偏差，采用多元线性回归模型计算生活质量得分的调整均值。
无任何合并症的参与者比例仅为20.2%。除高血压外，患有合并症的CCS在欧洲癌症研究与治疗组织生活质量问卷第3版的总体健康和功能量表以及癌症治疗功能评估通用量表上得分显著较低，但在欧洲癌症研究与治疗组织生活质量问卷第3版的症状量表上得分较高，这表明他们的生活质量较差，尤其是对于心血管、呼吸、消化和肌肉骨骼疾病。
中国CCS中合并症与生活质量之间存在显著关联，患有合并症的参与者总体生活质量得分较低。这些发现提示应对CCS进行全面护理。
