Zhang Yixiang, Yuan Yeqing, Chen Yufang, Wang Zhao, Li Fangfang, Zhao Qingsong
Department of Urology, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, People's Republic of China.
Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Onco Targets Ther. 2016 Jun 15;9:3565-9. doi: 10.2147/OTT.S106527. eCollection 2016.
The GSTP1 gene plays an important role in detoxification of carcinogens. GSTP1 gene polymorphisms may alter the susceptibility of urinary system cancer. Numerous studies have been performed to investigate the association between GSTP1 Ile105Val (rs1695 A>G) polymorphism and urinary system cancer risk. Nevertheless, the results remain controversial and only prostate cancer and bladder cancer are covered. We identified eligible studies from PubMed, Elsevier, and three equivalent Chinese databases including the Chinese National Knowledge Infrastructure, Wanfang, and Weipu. Pooled odds ratios and 95% confidence intervals were used to assess the strength of the association between GSTP1 Ile105Val polymorphism and urinary system cancer risk. In total, 11,762 cases and 15,150 controls from 51 studies were included in the final meta-analysis. The pooled results from all included studies showed a statistically significant association between GSTP1 Ile105Val polymorphism and urinary system cancer. In the subgroup analyses, the GSTP1 Ile105Val polymorphism was found to be significantly associated with prostate cancer risk and also a risk factor for urinary system cancer among Asians. In conclusion, our meta-analysis indicated that GSTP1 Ile105Val polymorphism was associated with urinary system cancer susceptibility, which needs to be validated by more rigorous data from further large-scale population studies with different ethnicities.
GSTP1基因在致癌物解毒过程中发挥着重要作用。GSTP1基因多态性可能会改变泌尿系统癌症的易感性。已经开展了大量研究来探究GSTP1 Ile105Val（rs1695 A>G）多态性与泌尿系统癌症风险之间的关联。然而，结果仍存在争议，且仅涵盖了前列腺癌和膀胱癌。我们从PubMed、爱思唯尔以及三个等效的中文数据库（包括中国知网、万方和维普）中识别出符合条件的研究。采用合并比值比和95%置信区间来评估GSTP1 Ile105Val多态性与泌尿系统癌症风险之间关联的强度。最终的荟萃分析共纳入了来自51项研究的11762例病例和15150例对照。所有纳入研究的合并结果显示，GSTP1 Ile105Val多态性与泌尿系统癌症之间存在统计学显著关联。在亚组分析中，发现GSTP1 Ile105Val多态性与前列腺癌风险显著相关，并且在亚洲人中也是泌尿系统癌症的一个风险因素。总之，我们的荟萃分析表明，GSTP1 Ile105Val多态性与泌尿系统癌症易感性相关，这需要通过来自不同种族的进一步大规模人群研究的更严格数据来验证。
