Avila Justina, Flowers Amina, Scott Travis M, Quilici Jill, Apostolova Liana G, Woo Ellen, Ringman John, Razani Jill
Department of Psychology, California State University, Northridge, CA, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
Department of Psychology, California State University, Northridge, CA, USA.
GeroPsych (Bern). 2015 Dec;28(4):191-200. doi: 10.1024/1662-9647/a000136. Epub 2015 Nov 26.
Mild cognitive impairment (MCI) is a risk state for dementia. The present study assessed daily functioning in MCI individuals (amnestic [aMCI] and nonamnestic [naMCI]) relative to those with Alzheimer's disease (AD) and healthy controls (NC). Twenty AD participants, 14 aMCI, 12 naMCI, and 30 healthy controls were administered the Direct Assessment of Functional Status (DAFS). The AD group performed poorer than all groups on all DAFS subscales. The aMCI group performed poorer than controls on the shopping subtests, while the naMCI group performed poorer than controls on only the free recall shopping. Finally, DAFS subscales discriminated the AD and aMCI groups well, but only recognition shopping discriminated between naMCI and aMCI individuals. These findings suggest that circumscribed ADL deficits distinguish subtypes of MCI and AD.
轻度认知障碍（MCI）是痴呆症的一种风险状态。本研究评估了MCI个体（遗忘型[aMCI]和非遗忘型[naMCI]）相对于阿尔茨海默病（AD）患者和健康对照（NC）的日常功能。对20名AD参与者、14名aMCI患者、12名naMCI患者和30名健康对照进行了功能状态直接评估（DAFS）。AD组在所有DAFS子量表上的表现均比所有组差。aMCI组在购物子测试中的表现比对照组差，而naMCI组仅在自由回忆购物方面比对照组差。最后，DAFS子量表能很好地区分AD组和aMCI组，但只有识别购物能区分naMCI个体和aMCI个体。这些发现表明，特定的日常生活活动缺陷可区分MCI和AD的亚型。
