轻度认知障碍、阿尔茨海默病及健康对照者的日常活动能力
Daily Activity Abilities in MCI, Alzheimer's Disease, and Healthy Controls.
作者信息
Avila Justina, Flowers Amina, Scott Travis M, Quilici Jill, Apostolova Liana G, Woo Ellen, Ringman John, Razani Jill
机构信息
Department of Psychology, California State University, Northridge, CA, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
Department of Psychology, California State University, Northridge, CA, USA.
出版信息
GeroPsych (Bern). 2015 Dec;28(4):191-200. doi: 10.1024/1662-9647/a000136. Epub 2015 Nov 26.
Abstract
Mild cognitive impairment (MCI) is a risk state for dementia. The present study assessed daily functioning in MCI individuals (amnestic [aMCI] and nonamnestic [naMCI]) relative to those with Alzheimer's disease (AD) and healthy controls (NC). Twenty AD participants, 14 aMCI, 12 naMCI, and 30 healthy controls were administered the Direct Assessment of Functional Status (DAFS). The AD group performed poorer than all groups on all DAFS subscales. The aMCI group performed poorer than controls on the shopping subtests, while the naMCI group performed poorer than controls on only the free recall shopping. Finally, DAFS subscales discriminated the AD and aMCI groups well, but only recognition shopping discriminated between naMCI and aMCI individuals. These findings suggest that circumscribed ADL deficits distinguish subtypes of MCI and AD.
摘要
轻度认知障碍（MCI）是痴呆症的一种风险状态。本研究评估了MCI个体（遗忘型[aMCI]和非遗忘型[naMCI]）相对于阿尔茨海默病（AD）患者和健康对照（NC）的日常功能。对20名AD参与者、14名aMCI患者、12名naMCI患者和30名健康对照进行了功能状态直接评估（DAFS）。AD组在所有DAFS子量表上的表现均比所有组差。aMCI组在购物子测试中的表现比对照组差，而naMCI组仅在自由回忆购物方面比对照组差。最后，DAFS子量表能很好地区分AD组和aMCI组，但只有识别购物能区分naMCI个体和aMCI个体。这些发现表明，特定的日常生活活动缺陷可区分MCI和AD的亚型。
相似文献
1
Daily Activity Abilities in MCI, Alzheimer's Disease, and Healthy Controls.轻度认知障碍、阿尔茨海默病及健康对照者的日常活动能力
GeroPsych (Bern). 2015 Dec;28(4):191-200. doi: 10.1024/1662-9647/a000136. Epub 2015 Nov 26.
2
Impact of Depressive Symptoms on Conversion from Mild Cognitive Impairment Subtypes to Alzheimer's Disease: A Community-Based Longitudinal Study.抑郁症状对轻度认知障碍亚型转化为阿尔茨海默病的影响：一项基于社区的纵向研究。
J Alzheimers Dis. 2016;51(2):405-15. doi: 10.3233/JAD-150603.
3
Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF.通过单分子阵列免疫检测法（Simoa）测量血浆和脑脊液中磷酸化tau蛋白181（p-tau181）对阿尔茨海默病轻度认知障碍进行鉴别诊断
Front Mol Neurosci. 2024 Jan 8;16:1288930. doi: 10.3389/fnmol.2023.1288930. eCollection 2023.
4
Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer's Disease.探索认知正常、遗忘型和非遗忘型轻度认知障碍以及阿尔茨海默病患者的言语流畅性策略。
Medicina (Kaunas). 2023 Oct 19;59(10):1860. doi: 10.3390/medicina59101860.
5
Predictors of independence in instrumental activities of daily living: Amnestic versus nonamnestic MCI.日常生活工具性活动独立性的预测因素：遗忘型与非遗忘型轻度认知障碍
J Clin Exp Neuropsychol. 2016 Nov;38(9):991-1004. doi: 10.1080/13803395.2016.1181716. Epub 2016 May 31.
6
Risk of progression to Alzheimer's disease for different neuropsychological Mild Cognitive Impairment subtypes: A hierarchical meta-analysis of longitudinal studies.不同神经心理学轻度认知障碍亚型进展为阿尔茨海默病的风险：纵向研究的层次荟萃分析。
Psychol Aging. 2018 Nov;33(7):1007-1021. doi: 10.1037/pag0000294. Epub 2018 Oct 4.
7
Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer's Disease.个体间的语言差异，认知正常者、遗忘型和非遗忘型 MCI 以及阿尔茨海默病患者。
Arch Clin Neuropsychol. 2023 May 22;38(4):525-536. doi: 10.1093/arclin/acac080.
8
The validity of amnestic MCI and non-amnestic MCI at age 75 in the prediction of Alzheimer's dementia and vascular dementia.75 岁时遗忘型轻度认知障碍和非遗忘型轻度认知障碍对阿尔茨海默病痴呆和血管性痴呆的预测效力。
Int Psychogeriatr. 2012 Jun;24(6):959-66. doi: 10.1017/S1041610211002870. Epub 2012 Feb 3.
9
Brain metabolism and cerebrospinal fluid biomarkers profile of non-amnestic mild cognitive impairment in comparison to amnestic mild cognitive impairment and normal older subjects.与遗忘型轻度认知障碍及正常老年受试者相比，非遗忘型轻度认知障碍的脑代谢和脑脊液生物标志物特征
Alzheimers Res Ther. 2015 Sep 15;7(1):58. doi: 10.1186/s13195-015-0143-0.
10
Activities of Daily Living and Depressive Symptoms in Patients with Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease.主观认知衰退、轻度认知障碍和阿尔茨海默病患者的日常生活活动与抑郁症状
J Alzheimers Dis. 2016;49(4):1043-50. doi: 10.3233/JAD-150785.
引用本文的文献
1
A systematic review of psychometric properties of questionnaires assessing activities of daily living among older adults with neurocognitive disorders.一项关于评估神经认知障碍老年人日常生活活动问卷的心理测量特性的系统评价。
Aust Occup Ther J. 2025 Feb;72(1):e13013. doi: 10.1111/1440-1630.13013.
2
Depressive Symptoms Associated With Social Participation in Older Adults Living With Mild Cognitive Impairment.轻度认知障碍老年人社交参与相关的抑郁症状
Gerontol Geriatr Med. 2024 Jan 5;10:23337214231223637. doi: 10.1177/23337214231223637. eCollection 2024 Jan-Dec.
3
Acceptance and Potential Impact of the eWALL Platform for Health Monitoring and Promotion in Persons with a Chronic Disease or Age-Related Impairment.接受和潜在影响的电子墙平台健康监测和促进的人患有慢性疾病或与年龄相关的损害。
Int J Environ Res Public Health. 2020 Oct 28;17(21):7893. doi: 10.3390/ijerph17217893.
4
Modification of everyday activities and its association with self-awareness in cognitively diverse older adults.日常活动的改变及其与认知多样化老年人自我意识的关系。
PLoS One. 2019 Nov 7;14(11):e0222769. doi: 10.1371/journal.pone.0222769. eCollection 2019.
5
The Functional Ability of MCI and Alzheimer's Patients Predicts Caregiver Burden.轻度认知障碍和阿尔茨海默病患者的功能能力可预测照料者负担。
GeroPsych (Bern). 2019 Mar;32(1):31-39. doi: 10.1024/1662-9647/a000200. Epub 2019 Mar 5.
6
Using Tablet-Based Assessment to Characterize Speech for Individuals with Dementia and Mild Cognitive Impairment: Preliminary Results.使用基于平板电脑的评估来表征痴呆症和轻度认知障碍患者的言语：初步结果。
AMIA Jt Summits Transl Sci Proc. 2019 May 6;2019:34-43. eCollection 2019.
7
A mixed-methods study of cultural beliefs about dementia and genetic testing among Mexicans and Mexican-Americans at-risk for autosomal dominant Alzheimer's disease.一项关于墨西哥人和有常染色体显性阿尔茨海默病风险的墨西哥裔美国人对痴呆症和基因检测的文化信仰的混合方法研究。
J Genet Couns. 2019 Oct;28(5):921-932. doi: 10.1002/jgc4.1133. Epub 2019 Jun 17.
8
Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.伴有抑郁障碍的患者中早发性与晚发性轻度认知功能障碍的临床和影像学特征。
Int J Geriatr Psychiatry. 2018 Dec;33(12):1604-1612. doi: 10.1002/gps.4955. Epub 2018 Jul 23.
本文引用的文献
1
Analysis of verbal fluency ability in amnestic and non-amnestic mild cognitive impairment.遗忘型和非遗忘型轻度认知障碍的言语流畅性能力分析。
Arch Clin Neuropsychol. 2013 Nov;28(7):721-31. doi: 10.1093/arclin/act058. Epub 2013 Aug 4.
2
Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes?经验衍生的轻度认知障碍亚型与传统亚型是否一致？
J Int Neuropsychol Soc. 2013 Jul;19(6):635-45. doi: 10.1017/S1355617713000313. Epub 2013 Apr 3.
3
Functional impairment as a defining feature of: amnestic MCI cognitive, emotional, and demographic correlates.作为遗忘型轻度认知障碍的定义特征：认知、情感和人口统计学相关性的功能障碍。
Int Psychogeriatr. 2012 Sep;24(9):1494-504. doi: 10.1017/S1041610212000622. Epub 2012 Apr 19.
4
Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementia.轻度认知障碍的修订标准可能会影响阿尔茨海默病痴呆的诊断。
Arch Neurol. 2012 Jun;69(6):700-8. doi: 10.1001/archneurol.2011.3152.
5
An examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment.老年人和轻度认知障碍者工具性日常生活活动评估研究。
J Clin Exp Neuropsychol. 2012;34(1):11-34. doi: 10.1080/13803395.2011.614598. Epub 2011 Nov 4.
6
Verbal serial list learning in mild cognitive impairment: a profile analysis of interference, forgetting, and errors.轻度认知障碍患者的言语序列学习：干扰、遗忘和错误的特征分析。
J Int Neuropsychol Soc. 2011 Sep;17(5):905-14. doi: 10.1017/S1355617711000944.
7
The nature of episodic memory deficits in MCI with and without vascular burden.有和无血管负担的 MCI 患者情景记忆缺陷的性质。
Neuropsychologia. 2011 Sep;49(11):3027-35. doi: 10.1016/j.neuropsychologia.2011.07.001. Epub 2011 Jul 7.
8
Outcomes of mild cognitive impairment by definition: a population study.根据定义的轻度认知障碍的结局：一项人群研究。
Arch Neurol. 2011 Jun;68(6):761-7. doi: 10.1001/archneurol.2011.101.
9
Patterns of deficits in daily functioning and cognitive performance of patients with Alzheimer disease.阿尔茨海默病患者日常功能和认知表现缺陷模式。
J Geriatr Psychiatry Neurol. 2011 Mar;24(1):23-32. doi: 10.1177/0891988710390812. Epub 2010 Dec 16.
10
Impact of impairment in instrumental activities of daily living and mild cognitive impairment on time to incident dementia: results of the Leipzig Longitudinal Study of the Aged.日常生活工具性活动能力受损和轻度认知障碍对痴呆发病时间的影响：莱比锡老年纵向研究的结果。
Psychol Med. 2011 May;41(5):1087-97. doi: 10.1017/S003329171000142X. Epub 2010 Jul 29.
Zotero 插件