Department of Neurology, Drexel University, College of Medicine, Philadelphia,PA 19013, USA.
J Int Neuropsychol Soc. 2011 Sep;17(5):905-14. doi: 10.1017/S1355617711000944.
Using cluster analysis Libon et al. (2010) found three verbal serial list-learning profiles involving delay memory test performance in patients with mild cognitive impairment (MCI). Amnesic MCI (aMCI) patients presented with low scores on delay free recall and recognition tests; mixed MCI (mxMCI) patients scored higher on recognition compared to delay free recall tests; and dysexecutive MCI (dMCI) patients generated relatively intact scores on both delay test conditions. The aim of the current research was to further characterize memory impairment in MCI by examining forgetting/savings, interference from a competing word list, intrusion errors/perseverations, intrusion word frequency, and recognition foils in these three statistically determined MCI groups compared to normal control (NC) participants. The aMCI patients exhibited little savings, generated more highly prototypic intrusion errors, and displayed indiscriminate responding to delayed recognition foils. The mxMCI patients exhibited higher saving scores, fewer and less prototypic intrusion errors, and selectively endorsed recognition foils from the interference list. dMCI patients also selectively endorsed recognition foils from the interference list but performed similarly compared to NC participants. These data suggest the existence of distinct memory impairments in MCI and caution against the routine use of a single memory test score to operationally define MCI.
利用聚类分析，Libon 等人（2010 年）发现轻度认知障碍（MCI）患者在延迟记忆测试表现中存在三种言语序列学习模式。遗忘型 MCI（aMCI）患者在延迟自由回忆和识别测试中得分较低；混合型 MCI（mxMCI）患者在识别测试中的得分高于延迟自由回忆测试；而执行功能障碍型 MCI（dMCI）患者在两种延迟测试条件下的得分相对完整。当前研究的目的是通过检查遗忘/保存、来自竞争词表的干扰、侵入错误/持续、侵入词频以及在这三种统计学确定的 MCI 组与正常对照组（NC）参与者相比，在延迟识别补笔中的识别错误，进一步描述 MCI 的记忆障碍。aMCI 患者表现出很少的保存，产生更多高度原型的侵入错误，并且对延迟识别补笔表现出不加区分的反应。mxMCI 患者表现出更高的保存分数，较少且不那么原型的侵入错误，并且选择性地认可来自干扰列表的识别补笔。dMCI 患者也选择性地认可来自干扰列表的识别补笔，但与 NC 参与者的表现相似。这些数据表明 MCI 存在不同的记忆障碍，并提醒人们不要常规使用单一记忆测试分数来操作定义 MCI。
