Kumar Ashish, Deopujari Chandrashekhar, Karmarkar Vikram
Department of Neurosurgery, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.
Asian J Neurosurg. 2016 Jul-Sep;11(3):313-4. doi: 10.4103/1793-5482.145062.
Meningiomas are benign tumors of the central nervous system. They have long term curability if they are excised completely. If not, they can recur after a prolonged period and can lead to increased morbidity during re-surgery. Recurrence is rarely associated with invasiveness. Usually de-differentiation in case of meningiomas is uncommon without any predisposing factors including different genetic mutations or radiation to the involved region. We report a case of a 38-year-old female who was operated for a benign para-sagittal meningioma 8 years back and subsequently developed an invasive recurrence off late. Also this time, the imaging morphology was slightly different for a meningioma and gross as well as microscopic findings were very atypical. Awareness for such cases must be there while dealing with recurrent meningiomas as invasiveness may not always be associated with adverse predisposing factors like radiation. As invasiveness is always a histopathological diagnosis, picking up such features on imaging is a daunting task and if done, can help neurosurgeons prognosticate such invasive recurrences in a better fashion.
脑膜瘤是中枢神经系统的良性肿瘤。如果能完全切除,它们具有长期可治愈性。如果不能完全切除,它们可能在很长一段时间后复发,并可能导致再次手术时发病率增加。复发很少与侵袭性相关。通常情况下,在没有包括不同基因突变或对受累区域进行放疗等任何诱发因素的情况下,脑膜瘤发生去分化并不常见。我们报告一例38岁女性病例,该患者8年前因良性矢状旁脑膜瘤接受手术,随后近期出现侵袭性复发。而且这次,脑膜瘤的影像学形态略有不同,大体及显微镜下表现都非常不典型。在处理复发性脑膜瘤时,必须对这类病例保持警惕,因为侵袭性并不总是与放疗等不良诱发因素相关。由于侵袭性始终是一种组织病理学诊断,在影像学上识别这些特征是一项艰巨的任务,如果能够做到,将有助于神经外科医生更好地预测此类侵袭性复发。