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结肠间置术后儿童发生恶性高热

Post-Operative Malignant Hyperthermia in a Child after Colon Interposition.

作者信息

Şahin Sevtap Hekimoğlu, İnan Mustafa, Aksu Burhan, Öner Naci, Çolak Alkin, Güzel Ahmet

机构信息

Department of Anaesthesiology and Reanimation, Trakya University Faculty of Medicine, Edirne, Turkey.

Department of Paediatric Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.

出版信息

Turk J Anaesthesiol Reanim. 2015 Dec;43(6):431-3. doi: 10.5152/TJAR.2015.04809. Epub 2015 Dec 1.

DOI:10.5152/TJAR.2015.04809
PMID:27366542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4894189/
Abstract

Malignant hyperthermia (MH) is a rare and potentially life threatening fatal complication of anaesthesia. We present a 2-year-old boy with late onset MH after colon interposition to replace the oesophagus under sevoflurane anaesthesia. The patient was treated with intravenous dantrolene sodium as well as cooling and controlled ventilation. Despite treatment, the patient developed cardiopulmonary arrest at 21 hours after the operation and died. It should be kept in mind that post-operative MH may develop during these types of operations with ischaemia-reperfusion injuries.

摘要

恶性高热(MH)是一种罕见且可能危及生命的麻醉致命并发症。我们报告一名2岁男孩,在七氟醚麻醉下进行结肠代食管术后发生迟发性恶性高热。患者接受了静脉注射丹曲林钠以及降温与控制通气治疗。尽管进行了治疗,患者仍在术后21小时发生心肺骤停并死亡。应牢记,在这些伴有缺血再灌注损伤的手术过程中可能会发生术后恶性高热。

相似文献

1
Post-Operative Malignant Hyperthermia in a Child after Colon Interposition.结肠间置术后儿童发生恶性高热
Turk J Anaesthesiol Reanim. 2015 Dec;43(6):431-3. doi: 10.5152/TJAR.2015.04809. Epub 2015 Dec 1.
2
Dantrolene sodium in the treatment of malignant hyperthermia. A case report.
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本文引用的文献

1
Postoperative malignant hyperthermia: an analysis of cases from the North American Malignant Hyperthermia Registry.术后恶性高热:北美恶性高热登记处病例分析
Anesthesiology. 2008 Nov;109(5):825-9. doi: 10.1097/ALN.0b013e31818958e5.
2
Minor increase of endtidal CO2 during sevoflurane-induced malignant hyperthermia.七氟醚诱导的恶性高热期间呼气末二氧化碳略有升高。
Paediatr Anaesth. 2007 Feb;17(2):180-2. doi: 10.1111/j.1460-9592.2006.02051.x.
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Sevoflurane stimulates inositol 1,4,5-trisphosphate in skeletal muscle.七氟醚刺激骨骼肌中的肌醇1,4,5-三磷酸。
Anesth Analg. 2000 Aug;91(2):440-5. doi: 10.1097/00000539-200008000-00040.
4
A clinical grading scale to predict malignant hyperthermia susceptibility.一种预测恶性高热易感性的临床分级量表。
Anesthesiology. 1994 Apr;80(4):771-9. doi: 10.1097/00000542-199404000-00008.
5
Postoperative malignant hyperthermia episodes in patients who received "safe" anaesthetics.
Can Anaesth Soc J. 1983 May;30(3 Pt 1):273-6. doi: 10.1007/BF03013807.