Köroğlu Gültürk, Tezcan Aysu Hayriye
Department of Pschiatry, Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, İstanbul, Turkey.
Clinic of Anaesthesiology and Reanimation, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Turk J Anaesthesiol Reanim. 2015 Dec;43(6):434-6. doi: 10.5152/TJAR.2015.54872. Epub 2015 Dec 1.
Propofol is a potent anaesthetic drug and also an effective sedative agent. Also, propofol may be used for non-anaesthetic purposes such as the treatment of seizures, migraine and tension headache in clinical practice. It has been abused, particularly among healthcare providers with high mortality rate. This report presents the case of a propofol-dependent patient who was an emergency medicine doctor with no difficulties in obtaining the drug. He himself visited our clinic for the treatment of propofol dependence. We started the patient's treatment with pharmacotherapeutic medicines and individual psychotherapy. Fourteen days after starting the therapy, the patient was discharged from hospital on his own will and he did not attend the follow-up visits in the outpatient clinic. Then, we were informed of his death, which was suspected to have occurred owing to drug intoxication in the hospital in which he worked. Nevertheless, the reason of death was important; the importance of this case report is to provide information regarding the drug's dependence profile. This is the first case report indicating propofol dependence in Turkey. Because of its easy access, rapid onset time and short duration of action, propofol dependence is increasing. We think that adding propofol to the controlled drug list and improving the knowledge of the clinicians regarding its abuse potential may limit the dependence cases.
丙泊酚是一种强效麻醉药物,也是一种有效的镇静剂。此外,在临床实践中,丙泊酚还可用于非麻醉目的,如治疗癫痫、偏头痛和紧张性头痛。它已被滥用,尤其是在医疗保健人员中,死亡率很高。本报告介绍了一例丙泊酚依赖患者的病例,该患者是一名急诊医生,获取该药物没有困难。他本人到我们诊所寻求丙泊酚依赖的治疗。我们开始对该患者进行药物治疗和个体心理治疗。治疗开始14天后,患者自行出院,且未到门诊进行随访。随后,我们得知他已死亡,据怀疑是在他工作的医院因药物中毒而死亡。然而,死亡原因很重要;本病例报告的重要性在于提供有关该药物依赖情况的信息。这是土耳其首例表明丙泊酚依赖的病例报告。由于丙泊酚易于获取、起效快且作用时间短,其依赖情况正在增加。我们认为,将丙泊酚列入管制药物清单并提高临床医生对其滥用可能性的认识,可能会限制依赖病例的发生。