Song Xue-Fei, Langenbucher Achim, Gatzioufas Zisis, Seitz Berthold, El-Husseiny Moatasem
Department of Ophthalmology, Saarland University Medical Center, Homburg Saar 66424, Germany; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Experimental Ophthalmology, Saarland University, Homburg Saar 66424, Germany.
Int J Ophthalmol. 2016 Jun 18;9(6):854-7. doi: 10.18240/ijo.2016.06.11. eCollection 2016.
To determine the impact of biometric characteristics on the biomechanical properties of the human cornea using the ocular response analyzer (ORA) and standard comprehensive ophthalmic examinations before and after standard phacoemulsification.
This study comprised 54 eyes with cataract with significant lens opacification in stages I or II that underwent phacoemulsification (2.8 mm incision). Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were measured by ORA preoperatively and at 1mo postoperatively. Biometric characteristics were derived from corneal topography [TMS-5, anterior equivalent (EQTMS) and cylindric (CYLTMS) power], corneal tomography [Casia, anterior and posterior equivalent (EQaCASIC, EQpCASIA) and cylindric (CYLaCASIA, CYLpCASIA) power], keratometry [IOLMaster, anterior equivalent (EQIOL) and cylindric (CYLIOL) power] and autorefractor [anterior equivalent (EQAR)]. Results from ORA were analyzed and correlated with those from all other examinations taken at the same time point.
Preoperatively, CH correlated with EQpCASIA and CYLpCASIA only (P=0.001, P=0.002). Postoperatively, IOPg and IOPcc correlated with all equivalent powers (EQTMS, EQIOL, EQAR, EQaCASIA and EQpCASIA) (P=0.001, P=0.007, P=0.001, P=0.015, P=0.03 for IOPg and P<0.001, P=0.003, P<0.001, P=0.009, P=0.014 for IOPcc). CH correlated postoperatively with EQaCASIA and EQpCASIC only (P=0.021, P=0.022).
Biometric characteristics may significantly affect biomechanical properties of the cornea in terms of CH, IOPcc and IOPg before, but even more after cataract surgery.
使用眼反应分析仪（ORA）以及标准白内障超声乳化术前后的标准综合眼科检查，确定生物特征对人角膜生物力学特性的影响。
本研究纳入54例患有I期或II期明显晶状体混浊的白内障患者的眼睛，这些眼睛接受了白内障超声乳化术（2.8毫米切口）。术前及术后1个月通过ORA测量角膜滞后（CH）、角膜阻力因子（CRF）、Goldmann相关眼压（IOPg）和角膜补偿眼压（IOPcc）。生物特征源自角膜地形图 [TMS-5，前表面等效曲率（EQTMS）和柱镜度数（CYLTMS）]、角膜断层扫描 [Casia，前后表面等效曲率（EQaCASIC、EQpCASIA）和柱镜度数（CYLaCASIA、CYLpCASIA）]、角膜曲率计 [IOLMaster，前表面等效曲率（EQIOL）和柱镜度数（CYLIOL）] 以及自动验光仪 [前表面等效曲率（EQAR）]。分析ORA的结果，并将其与在同一时间点进行的所有其他检查结果进行关联。
术前，CH仅与EQpCASIA和CYLpCASIA相关（P = 0.001，P = 0.002）。术后，IOPg和IOPcc与所有等效曲率（EQTMS、EQIOL、EQAR、EQaCASIA和EQpCASIA）相关（IOPg的P值分别为0.001、0.007、0.001、0.015、0.03；IOPcc的P值分别为<0.001、0.003、<0.001、0.009、0.014）。术后CH仅与EQaCASIA和EQpCASIC相关（P = 0.021，P = 0.022）。
生物特征在白内障手术前可能会显著影响角膜的生物力学特性，包括CH、IOPcc和IOPg，但在白内障手术后影响更大。
