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德谷胰岛素/门冬胰岛素共混制剂的实用应用:一项跨国共识声明。

Pragmatic use of insulin degludec/insulin aspart co-formulation: A multinational consensus statement.

作者信息

Kalra Sanjay, Latif Zafar A, Comlekci Abdurrahman, Galvez Guillermo Gonzalez, Malik Rached, Pathan Md Faruque, Kumar Ajay

机构信息

Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.

Director, Department of Endocrinology, BIRDEM, Dhaka, Bangladesh.

出版信息

Indian J Endocrinol Metab. 2016 Jul-Aug;20(4):542-5. doi: 10.4103/2230-8210.182980.

DOI:10.4103/2230-8210.182980
PMID:27366723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4911846/
Abstract

Insulin degludec/insulin aspart (IDegAsp) is a modern coformulation of ultra-long-acting basal insulin degludec, with rapid-acting insulin aspart. IDegAsp provides effective, safe, well-tolerated glycemic control, with a low risk of hypoglycemia while allowing flexibility in meal patterns and timing of administration. This consensus statement describes a pragmatic framework to identify patients who may benefit from IDegAsp therapy. It highlights the utility of IDegAsp in type 2 diabetic patients who are insulin-naive, suboptimally controlled on basal or premixed insulin, or dissatisfied with basal-bolus regimens. It also describes potential IDegAsp usage in type 1 diabetic patients.

摘要

德谷胰岛素/门冬胰岛素(IDegAsp)是超长效基础胰岛素德谷胰岛素与速效门冬胰岛素的现代复方制剂。IDegAsp能提供有效、安全且耐受性良好的血糖控制,低血糖风险低,同时在进餐模式和给药时间方面具有灵活性。本共识声明描述了一个实用框架,以识别可能从IDegAsp治疗中获益的患者。它强调了IDegAsp在初治、基础胰岛素或预混胰岛素治疗血糖控制不佳或对基础-餐时胰岛素方案不满意的2型糖尿病患者中的应用价值。它还描述了IDegAsp在1型糖尿病患者中的潜在用法。

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本文引用的文献

1
Clinical use of Insulin Degludec: Practical Experience and Pragmatic Suggestions.德谷胰岛素的临床应用:实践经验与实用建议
N Am J Med Sci. 2015 Mar;7(3):81-5. doi: 10.4103/1947-2714.153918.
2
Insulin Degludec Aspart: The First Co-formulation of Insulin Analogues.胰岛素德谷门冬双胰岛素:首个胰岛素类似物复方制剂
Diabetes Ther. 2014 Jun;5(1):65-72. doi: 10.1007/s13300-014-0067-x. Epub 2014 May 15.
3
Comparison of National/Regional Diabetes Guidelines for the Management of Blood Glucose Control in non-Western Countries.非西方国家国家/地区糖尿病管理血糖控制指南比较。
Diabetes Ther. 2013 Jun;4(1):91-102. doi: 10.1007/s13300-013-0022-2. Epub 2013 May 4.
4
Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial.比较德谷胰岛素/门冬胰岛素可溶性复方制剂与预混门冬胰岛素 30 在 2 型糖尿病中的疗效:一项随机试验。
Eur J Endocrinol. 2012 Aug;167(2):287-94. doi: 10.1530/EJE-12-0293. Epub 2012 Jun 1.
5
Degludec insulin: A novel basal insulin.德谷胰岛素:一种新型基础胰岛素。
Indian J Endocrinol Metab. 2011 Jul;15(Suppl 1):S12-6. doi: 10.4103/2230-8210.83056.
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Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects.门冬胰岛素(B28 天冬酰胺胰岛素):人胰岛素的速效类似物:在健康非糖尿病受试者中与常规人胰岛素相比的吸收动力学和作用曲线
Diabetes Care. 1999 Sep;22(9):1501-6. doi: 10.2337/diacare.22.9.1501.