Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
Jinghua Anti-cancer Pharmaceutical Engineering Center , Nantong 226407, China.
J Org Chem. 2016 Aug 5;81(15):6887-92. doi: 10.1021/acs.joc.6b01286. Epub 2016 Jul 18.
An efficient transition-metal-free fluoroarylation reaction of N-aryl diazoacetamides with NFSI (N-fluorobenzenesulfonimide) is described. This reaction directly provides 3-fluorooxindole derivatives in yields of 67-93% with high selectivity via a carbene-free process under mild reaction conditions.
本文描述了一种高效的无过渡金属氟芳基化反应,即 N-芳基重氮乙酰胺与 NFSI(N-氟苯磺酰亚胺)的反应。在温和的反应条件下,通过无卡宾过程,该反应以 67-93%的高产率和高选择性直接提供 3-氟色酮衍生物。