无过渡金属氟代重氮乙酰胺：3-氟代氧吲哚的补充方法。
Transition-Metal-Free Fluoroarylation of Diazoacetamides: A Complementary Approach to 3-Fluorooxindoles.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
Jinghua Anti-cancer Pharmaceutical Engineering Center , Nantong 226407, China.
出版信息
J Org Chem. 2016 Aug 5;81(15):6887-92. doi: 10.1021/acs.joc.6b01286. Epub 2016 Jul 18.
PMID:27366998
Abstract
An efficient transition-metal-free fluoroarylation reaction of N-aryl diazoacetamides with NFSI (N-fluorobenzenesulfonimide) is described. This reaction directly provides 3-fluorooxindole derivatives in yields of 67-93% with high selectivity via a carbene-free process under mild reaction conditions.
摘要
本文描述了一种高效的无过渡金属氟芳基化反应，即 N-芳基重氮乙酰胺与 NFSI（N-氟苯磺酰亚胺）的反应。在温和的反应条件下，通过无卡宾过程，该反应以 67-93%的高产率和高选择性直接提供 3-氟色酮衍生物。
Zotero 插件