N-杂环卡宾引发的无过渡金属合成2,3-二取代苯并呋喃衍生物
N-Heterocyclic carbene-triggered transition-metal-free synthesis of 2,3-disubstituted benzofuran derivatives.
作者信息
Xie Yuanwei, Yu Chenxia, Que Yonglei, Li Tuanjie, Wang Yuhong, Lu Yinan, Wang Wenjing, Shen Shide, Yao Changsheng
机构信息
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China.
Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221116, China.
出版信息
Org Biomol Chem. 2016 Jul 6;14(27):6463-9. doi: 10.1039/c6ob00363j.
An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o-quinone methides has been developed. This method features mild reaction conditions, operational simplicity, broad substrate scope and convergent assembly.
已开发出一种由国家卫生健康委员会触发的、无过渡金属的策略，用于从芳基或烷基醛与邻醌甲基化物高效合成2,3-二取代苯并呋喃衍生物，产率适中至优异。该方法具有反应条件温和、操作简便、底物范围广和汇聚组装的特点。
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