Karahan Eyyup, Tuncer İbrahim, Er Duygu, Zengin Mehmet Ozgur
a Sifa University , Department of Ophthalmology , Izmir , Turkey.
b Alfagoz Eye Center , Izmir , Turkey.
Semin Ophthalmol. 2017;32(5):602-606. doi: 10.3109/08820538.2016.1139736. Epub 2016 Jul 1.
This study was designed to compare the normal and glaucomatous eyes regarding retinal nerve fiber layer (RNFL) thickness and peripapillary choroidal thickness (PCT), and to investigate the correlation of RNFL thickness and PCT.
Subjects were selected as a convenience sample of those from a tertiary referral practice of glaucoma. Thirty-two glaucomatous eyes were accepted as group 1; 30 normal eyes were accepted as group 2. Groups were compared for RNFL thickness and PCT. Correlations of RNFL thickness and PCT were assessed for each peripapillary location.
Mean inferior and superior RNFL thickness in group 1 were significantly lower than the control group; mean thicknesses of temporal and nasal quadrants were not different in the two groups. Mean PCT at 500 µm distance in the inferior, at 1500 µm distance in the superior, at 500, 1000, and 1500 µm distance in the temporal, and at 1000 and 1500 µm distance in nasal quadrants were found to be significantly thinner in the glaucoma group compared with the control group. Retinal nerve fiber thickness was strongly correlated with PCT at all points of inferior quadrants at 500 µm distance in the superior. There was no correlation between RNFL thickness and PCT at any point in the control group.
Peripapillary choroidal thickness was thinner in glaucomatous eyes compared with normal eyes. Correlation of PCT and RNFL thickness found in patients with glaucoma did not exist in normal subjects.
本研究旨在比较正常眼和青光眼眼中视网膜神经纤维层（RNFL）厚度及视乳头周围脉络膜厚度（PCT），并研究RNFL厚度与PCT之间的相关性。
选取青光眼三级转诊机构的患者作为便利样本。32只青光眼眼作为第1组；30只正常眼作为第2组。比较两组的RNFL厚度和PCT。评估每个视乳头周围位置的RNFL厚度与PCT的相关性。
第1组下侧和上侧RNFL平均厚度显著低于对照组；两组颞侧和鼻侧象限的平均厚度无差异。与对照组相比，青光眼组在下侧500 µm处、上侧1500 µm处、颞侧500 µm、1000 µm和1500 µm处以及鼻侧象限1000 µm和1500 µm处的平均PCT明显更薄。视网膜神经纤维厚度与上侧500 µm处下侧象限所有点的PCT密切相关。对照组中RNFL厚度与PCT在任何点均无相关性。
与正常眼相比，青光眼眼的视乳头周围脉络膜厚度更薄。青光眼患者中发现的PCT与RNFL厚度的相关性在正常受试者中不存在。
