Park Ji-Hye, Yoo Chungkwon, Kim Yong Yeon
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Medicine (Baltimore). 2018 Jun;97(23):e11001. doi: 10.1097/MD.0000000000011001.
The aim of this study was to evaluate the regional variations of peripapillary choroidal thickness (PCT) in normal-tension glaucoma (NTG) patients with a retinal nerve fiber layer (RNFL) defect localized to a single superior or inferior hemifield. This is a retrospective, cross-sectional study.Ninety-five NTG patients and 53 normal subjects were divided into 3 groups: 34 eyes with a superior RNFL defect (group A), 61 eyes with an inferior RNFL defect (group B), and 53 normal eyes (group C). The average, quadrant, and clock-hour RNFL thickness (RNFLT) and PCT were measured using spectral-domain optical coherence tomography. Choroidal thickness ratio (CTR) was defined as the ratio of the measured PCT at a quadrant or a clock-hour position to the average PCT of an individual. The PCT, CTR, and RNFLT were compared among 3 groups.The average PCT of NTG patients was thinner compared to that of healthy subjects (154.17 vs. 180.65 μm, P < .001). Although the average, quadrant, and clock-hour PCTs were not different between groups A and B, the CTR at 11 o'clock was significantly lower in group A compared to that of group B. The 11 o'clock CTR was an independent factor for the initial location of a RNFL defect (P = .03).Eyes with NTG showed regional differences in CTR according to the hemisphere location of their initial RNFL damage. Therefore, CTR may be more useful than the absolute PCT value to assess regional PCT differences in eyes with NTG.
本研究的目的是评估视网膜神经纤维层（RNFL）缺损局限于单个上半视野或下半视野的正常眼压性青光眼（NTG）患者视乳头周围脉络膜厚度（PCT）的区域差异。这是一项回顾性横断面研究。95例NTG患者和53例正常受试者被分为3组：34只患有上半视野RNFL缺损的眼睛（A组），61只患有下半视野RNFL缺损的眼睛（B组），以及53只正常眼睛（C组）。使用频域光学相干断层扫描测量平均、象限和钟点RNFL厚度（RNFLT）以及PCT。脉络膜厚度比（CTR）定义为在象限或钟点位置测量的PCT与个体平均PCT的比值。比较3组之间的PCT、CTR和RNFLT。与健康受试者相比，NTG患者的平均PCT更薄（154.17对180.65μm，P<0.001）。虽然A组和B组之间的平均、象限和钟点PCT没有差异，但A组11点处的CTR显著低于B组。11点处的CTR是RNFL缺损初始位置的独立因素（P=0.03）。NTG患者的眼睛根据其初始RNFL损伤的半球位置在CTR上显示出区域差异。因此，在评估NTG患者眼睛的区域PCT差异时，CTR可能比绝对PCT值更有用。
