无金属条件下通过基于烯胺酮和醛的串联反应构建稠环合成全取代吡啶
Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes.
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, P. R. China.
College of Basic Medical Sciences, Zhejiang Chinese Medical University , Hangzhou, Zhejiang 310053, P. R. China.
出版信息
J Org Chem. 2016 Aug 5;81(15):6826-31. doi: 10.1021/acs.joc.6b01149. Epub 2016 Jul 15.
PMID:27367181
Abstract
An unprecedented domino reaction involving primary enaminones/enaminoesters and aldehydes has been developed for the synthesis of fully substituted pyridines. The construction of the products has been accomplished via the cascade generation of two C-C and one C-N bond by simply using TfOH as a promoter.
摘要
一种前所未有的级联反应，涉及主要的烯胺酮/烯胺酯和醛，已经被开发用于完全取代的吡啶的合成。通过简单地使用 TfOH 作为促进剂，通过级联生成两个 C-C 和一个 C-N 键来完成产物的构建。
Zotero 插件