Takkar Brijesh, Chandra Parijat, Shah Ritu, Bhatia Indrish, Roy Sangeeta, Sihota Ramanjit
a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
Semin Ophthalmol. 2017;32(6):672-675. doi: 10.3109/08820538.2016.1169301. Epub 2016 Jul 1.
To evaluate the effect of intravenous mannitol (IVM) on intraocular pressure (IOP) in vitrectomized eyes.
Thirty-one patients with raised IOP after retinal surgery with silicone oil injection were included. Patients were administered IVM (20% solution, 1g/Kg, over 30 minutes) and IOP was noted at regular intervals. IOP reduction in vitrectomized eyes (Group 1) was compared with the normal eyes (Group 2).
Percentage IOP reduction was higher in Group 1 than in Group 2 at all time intervals, 24.5% vs. 19.2% at 15 minutes (p=0.34), 22.6% vs. 9.8% at 45 minutes (p=0.003), 19.1% vs. 9.9% at two hours (p=0.023), and 16.1% vs. 7.8% at four hours (p=0.04), respectively. In Group 1, 40% eyes had an IOP reduction of 2-6 mmHg while 30% eyes had IOP reduction >6 mmHg at four hours post-IVM.
IVM is useful for short-term IOP reduction in vitrectomized eyes. IOP reduction is independent of baseline IOP, and sustained and higher as compared to normal eyes.
评估静脉注射甘露醇（IVM）对玻璃体切除术后眼内压（IOP）的影响。
纳入31例视网膜手术后硅油注入导致眼压升高的患者。给予患者静脉注射甘露醇（20%溶液，1g/kg，30分钟内滴注完毕），并定期记录眼压。将玻璃体切除术后的眼睛（第1组）的眼压降低情况与正常眼睛（第2组）进行比较。
在所有时间间隔内，第1组的眼压降低百分比均高于第2组，15分钟时分别为24.5%和19.2%（p = 0.34），45分钟时为22.6%和9.8%（p = 0.003），两小时时为19.1%和9.9%（p = 0.023），四小时时为16.1%和7.8%（p = 0.04）。在第1组中，40%的眼睛在静脉注射甘露醇后4小时眼压降低2 - 6 mmHg，而30%的眼睛眼压降低>6 mmHg。
静脉注射甘露醇对玻璃体切除术后的眼睛短期降低眼压有效。眼压降低与基线眼压无关，与正常眼睛相比持续时间更长且降低幅度更大。
