静脉注射甘露醇对玻璃体切除联合硅油填充眼眼压的影响。

Effect of Intravenous Mannitol on Intraocular Pressure in Vitrectomized Silicone-Oil-Filled Eyes.

作者信息

Takkar Brijesh, Chandra Parijat, Shah Ritu, Bhatia Indrish, Roy Sangeeta, Sihota Ramanjit

机构信息

a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.

出版信息

Semin Ophthalmol. 2017;32(6):672-675. doi: 10.3109/08820538.2016.1169301. Epub 2016 Jul 1.

DOI:10.3109/08820538.2016.1169301

PMID:27367233

Abstract

PURPOSE

To evaluate the effect of intravenous mannitol (IVM) on intraocular pressure (IOP) in vitrectomized eyes.

METHODS

Thirty-one patients with raised IOP after retinal surgery with silicone oil injection were included. Patients were administered IVM (20% solution, 1g/Kg, over 30 minutes) and IOP was noted at regular intervals. IOP reduction in vitrectomized eyes (Group 1) was compared with the normal eyes (Group 2).

RESULT

Percentage IOP reduction was higher in Group 1 than in Group 2 at all time intervals, 24.5% vs. 19.2% at 15 minutes (p=0.34), 22.6% vs. 9.8% at 45 minutes (p=0.003), 19.1% vs. 9.9% at two hours (p=0.023), and 16.1% vs. 7.8% at four hours (p=0.04), respectively. In Group 1, 40% eyes had an IOP reduction of 2-6 mmHg while 30% eyes had IOP reduction >6 mmHg at four hours post-IVM.

CONCLUSION

IVM is useful for short-term IOP reduction in vitrectomized eyes. IOP reduction is independent of baseline IOP, and sustained and higher as compared to normal eyes.

摘要

目的

评估静脉注射甘露醇（IVM）对玻璃体切除术后眼内压（IOP）的影响。

方法

纳入31例视网膜手术后硅油注入导致眼压升高的患者。给予患者静脉注射甘露醇（20%溶液，1g/kg，30分钟内滴注完毕），并定期记录眼压。将玻璃体切除术后的眼睛（第1组）的眼压降低情况与正常眼睛（第2组）进行比较。

结果

在所有时间间隔内，第1组的眼压降低百分比均高于第2组，15分钟时分别为24.5%和19.2%（p = 0.34），45分钟时为22.6%和9.8%（p = 0.003），两小时时为19.1%和9.9%（p = 0.023），四小时时为16.1%和7.8%（p = 0.04）。在第1组中，40%的眼睛在静脉注射甘露醇后4小时眼压降低2 - 6 mmHg，而30%的眼睛眼压降低>6 mmHg。