Glaucoma Services, Aravind Eye Hospital, Coimbatore, Tamil Nadu, India.
J Glaucoma. 2019 Apr;28(4):318-320. doi: 10.1097/IJG.0000000000001158.
To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and nonvitrectomized eyes.
Prospective comparative case study. Eyes with IOP≥40 mm Hg were included. Eyes which are vitrectomized and silicon oil filled were classified as group 1, and nonvitrectomized open-angle eyes were classified as group 2. Mannitol (20%, 1 g/kg) was administered intravenously over 30 minutes, and IOP was recorded at 30 minutes interval till 2 hours and at the third and fourth hour from the start of mannitol.
Thirty eyes (patients) were recruited in each group. Mean (SD) IOP reduced from 48.5±5.2 to 43.7±8 at 30 minutes, 40.7±8.4 at 60 minutes, 37.3±9.6 at 90 minutes, 35.6±10.4 at 2 hours, 34±10.7 at 3 hours, and 33±11.2 mm Hg at 4 hours in group 1, and from 48.9±6.5 to 43.2±8.6 at 30 minutes, 40.2±7.8 at 60 minutes, 36.7±7.3 at 90 minutes, 35.1±7.7 at 2 hours, 34.2±8.8 at 3 hours, and 35.7±9.4 mm Hg at 4 hours in group 2. There was a significant reduction in IOP at each time point compared with baseline in both the groups (P<0.001). There was no significant difference in IOP between the 2 groups at each time point.
Mannitol reduces IOP significantly in both vitrectomized and nonvitrectomized eyes.
比较甘露醇降低玻璃体切割和未玻璃体切割眼眼压（IOP）的效果。
前瞻性对比病例研究。纳入IOP≥40mmHg 的眼。玻璃体切割硅油填充眼为 1 组，非玻璃体切割开角眼为 2 组。甘露醇（20%，1g/kg）静脉滴注 30 分钟，记录 30 分钟至 2 小时，第 3、4 小时眼压。
每组纳入 30 只眼（患者）。1 组眼压从 48.5±5.2mmHg 降至 30 分钟时 43.7±8mmHg、60 分钟时 40.7±8.4mmHg、90 分钟时 37.3±9.6mmHg、2 小时时 35.6±10.4mmHg、3 小时时 34±10.7mmHg、4 小时时 33±11.2mmHg；2 组从 48.9±6.5mmHg 降至 30 分钟时 43.2±8.6mmHg、60 分钟时 40.2±7.8mmHg、90 分钟时 36.7±7.3mmHg、2 小时时 35.1±7.7mmHg、3 小时时 34.2±8.8mmHg、4 小时时 35.7±9.4mmHg。两组各时间点与基线相比 IOP 均显著降低（P<0.001）。两组各时间点间 IOP 无显著差异。
甘露醇可显著降低玻璃体切割和未玻璃体切割眼的眼压。
