Redl H, Schlag G, Thurnher M, Traber L D, Traber D L
Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria.
Circ Shock. 1989 Jun;28(2):101-8.
Peptidoglycans (PG) and lipopolysaccharides (LPS) are cell wall constituents of bacteria. The relative contents vary significantly between gram-negative and gram-positive strains. Since both strains take part in clinical septicemia, we compared hemodynamic and permeability properties in a sheep model with chronic instrumentation and lung lymph drainage. The cardiovascular reaction patterns of PG and LPS were comparable at very different dose levels, with LPS being 10,000-fold more potent. Continuous infusion produced an increase in lung permeability (only with LPS) and cardiac output, as well as fever, to mimic the hyperdynamic situation in early septicemia.
肽聚糖（PG）和脂多糖（LPS）是细菌的细胞壁成分。革兰氏阴性菌和革兰氏阳性菌菌株中的相对含量差异显著。由于这两种菌株都参与临床败血症，我们在一个具有慢性仪器植入和肺淋巴引流的绵羊模型中比较了血流动力学和通透性特性。PG和LPS在非常不同的剂量水平下的心血管反应模式具有可比性，LPS的效力要强10000倍。持续输注会导致肺通透性增加（仅LPS会导致）、心输出量增加以及发热，以模拟早期败血症中的高动力状态。
