Redl H, Schlag G, Lamche H
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
Circ Shock. 1990 Jun;31(2):183-92.
There have been reports that the administration of TNF produces many of the cardiopulmonary changes seen with endotoxin (LPS). We asked whether all of LPS effects can be mimicked by TNF infusion. The effects of infusion of (human recombinant) TNF (50 micrograms/kg/30 min) and LPS (3 micrograms/kg/30 min) on permeability characteristics of sheep lungs were compared. Thirteen sheep were chronically instrumented for cardiopulmonary studies including lung lymph data. Infusion of LPS and TNF result in an increase of body temperature and lung lymph protein clearance (measured as the product of Lymph Flow and Lymph/Plasma Protein Ratio). The two responses had entirely different time courses. This might be related to the significantly longer period of pulmonary hypertension (MPAP) with LPS, which was only transient with TNF. Similar differences in plasma levels of thromboxane B2 (TxB2) were also noted. There were also differences in leukocyte kinetics, arterial blood gases, and plasma lactate levels. This indicates that although TNF infusion results in an increased pulmonary microvascular permeability, this event occurs without concomitant changes in thromboxane metabolism and exhibits time characteristics somewhat different from endotoxin.
有报道称，给予肿瘤坏死因子（TNF）会产生许多与内毒素（LPS）所见相似的心肺变化。我们探讨了TNF输注是否能模拟LPS的所有作用。比较了输注（重组人）TNF（50微克/千克/30分钟）和LPS（3微克/千克/30分钟）对绵羊肺通透性特征的影响。13只绵羊长期植入仪器用于心肺研究，包括肺淋巴数据。输注LPS和TNF导致体温升高和肺淋巴蛋白清除率增加（以淋巴流量与淋巴/血浆蛋白比率的乘积衡量）。这两种反应的时间进程完全不同。这可能与LPS导致的肺动脉高压（平均肺动脉压）持续时间显著更长有关，而TNF导致的肺动脉高压只是短暂的。血栓素B2（TxB2）血浆水平也存在类似差异。白细胞动力学、动脉血气和血浆乳酸水平也存在差异。这表明，虽然输注TNF会导致肺微血管通透性增加，但这一过程并未伴随血栓素代谢的变化，且呈现出与内毒素有所不同的时间特征。
