Tighe D, Moss R, Heath M F, Hynd J, Bennett E D
Department of Medicine 1, St. George's Hospital Medical School, London, England.
Circ Shock. 1989 Jun;28(2):159-64.
This study examines the changes in pulmonary leucostasis and capillary ultrastructure in 18 rabbits divided into three groups. Those in the first group were sham operated, and those in the second and third groups underwent peritonitis induction; those in the latter group were treated with pentoxifylline (PTF). White blood cells (WBC) were counted, and tissue area, total capillary area, and capillary patency were measured from electron micrographs of lung tissue. Pulmonary WBCs were 1.2 per unit field in the sham group, 9.7 in the test group (P less than 0.001 compared with sham), and 2.5 in the PTF group (P less than 0.001 compared with sham). Capillary patency was 53 +/- 5% in the sham group, 12 +/- 4% (P less than 0.001 compared with sham) in the test group, and 24 +/- 2% (P less than 0.001 compared with sham) in the PTF group. Pentoxifylline treatment attenuates pulmonary leucostasis, pulmonary capillary occlusion, and endothelial and epithelial damage associated with peritonitis in rabbits. This study shows that PTF warrants investigation into its potential protective effects on the lungs in clinical sepsis.
本研究观察了18只家兔的肺白细胞淤滞和毛细血管超微结构的变化，这些家兔被分为三组。第一组进行假手术，第二组和第三组诱导腹膜炎；第三组用己酮可可碱（PTF）治疗。计数白细胞（WBC），并从肺组织电子显微照片中测量组织面积、毛细血管总面积和毛细血管通畅率。假手术组每单位视野的肺白细胞数为1.2，试验组为9.7（与假手术组相比P<0.001），PTF组为2.5（与假手术组相比P<0.001）。假手术组毛细血管通畅率为53±5%，试验组为12±4%（与假手术组相比P<0.001），PTF组为24±2%（与假手术组相比P<0.001）。己酮可可碱治疗可减轻家兔腹膜炎相关的肺白细胞淤滞、肺毛细血管阻塞以及内皮和上皮损伤。本研究表明，PTF值得研究其在临床脓毒症中对肺的潜在保护作用。
