Tighe D, Moss R, Hynd J, Boghossian S, al-Saady N, Heath M F, Bennett E D
St. George's Hospital Medical School, London, England.
Crit Care Med. 1990 Feb;18(2):184-9. doi: 10.1097/00003246-199002000-00012.
We investigated pentoxifylline (PTF) as a pretreatment of septic syndrome in pigs with fecal peritonitis. In the untreated group there was a progressive decrease in mean arterial pressure (MAP), cardiac output, mean pulmonary artery wedge pressure (WP), and a progressive rise in mean pulmonary artery pressure (MPAP), pulmonary vascular resistance (PVR), systemic vascular resistance (SVR), heart rate (HR), and core temperature (T). In those pigs given PTF there was a significantly smaller increase in SVR throughout and in PVR after 270 min. No significant differences were seen in MAP, MPAP, WP, HR, and T. Neutrophil adhesiveness did not change in the untreated group. However, it decreased markedly with PTF, both before and after peritonitis induction. Electron microscopy of the lungs, liver, and spleen in the test group showed severe damage, with endothelial disruption, capillary or sinusoidal occlusion, leukostasis, and neutrophil degranulation. Pretreatment with PTF attenuated these changes.
我们研究了己酮可可碱（PTF）对粪便性腹膜炎猪败血症综合征的预处理作用。在未治疗组中，平均动脉压（MAP）、心输出量、平均肺动脉楔压（WP）逐渐降低，而平均肺动脉压（MPAP）、肺血管阻力（PVR）、体循环血管阻力（SVR）、心率（HR）和核心体温（T）逐渐升高。在给予PTF的猪中，整个过程中SVR的升高明显较小，270分钟后PVR的升高也明显较小。在MAP、MPAP、WP、HR和T方面未观察到显著差异。未治疗组中性粒细胞黏附性未改变。然而，在诱导腹膜炎前后，PTF均使其显著降低。试验组肺、肝和脾的电子显微镜检查显示严重损伤，伴有内皮破坏、毛细血管或血窦阻塞、白细胞淤滞和中性粒细胞脱颗粒。PTF预处理减轻了这些变化。
