Patel Shalinkumar, Dereddy Narendra, Talati Ajay J, Gaston Kan, Dhanireddy Ramasubbareddy
Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Department of Pharmacy, Regional One Health, Memphis, Tennessee.
Am J Perinatol. 2017 Jan;34(2):169-173. doi: 10.1055/s-0036-1584927. Epub 2016 Jul 1.
To study the characteristics of very low birth weight (VLBW) infants receiving glycerin suppositories (GS) and evaluate the association of GS use with outcomes. This is a retrospective study of VLBW infants admitted to a level III neonatal intensive care unit. Infants with birth weight between 500 and 1,499 g were evaluated. We evaluated the frequency of GS use and compared the characteristics and outcomes of the GS group with the no-GS group. Multivariate analyses controlling for gestational age and small for gestational age status were performed to study the effect of GS on outcomes. A total of 1,073 infants were included in the study. Out of those, 527 (49.1%) infants received GS. Incidence of necrotizing enterocolitis was not significantly different between the two groups, while days to reach full enteral feeds and length of hospital stay were significantly longer in the GS group. Frequent use of GS warrants further prospective studies to evaluate its safety and efficacy in view of our study showing association with longer time to reach full enteral feeds. We speculate that GS use could be a marker for gastrointestinal dysmotility and hence the association with unfavorable clinical outcomes.
研究接受甘油栓剂（GS）的极低出生体重（VLBW）婴儿的特征，并评估使用GS与预后的相关性。 这是一项对入住三级新生儿重症监护病房的VLBW婴儿进行的回顾性研究。对出生体重在500至1499克之间的婴儿进行评估。我们评估了GS的使用频率，并比较了GS组和非GS组的特征及预后。进行多变量分析以控制胎龄和小于胎龄状态，从而研究GS对预后的影响。 共有1073名婴儿纳入本研究。其中，527名（49.1%）婴儿接受了GS。两组之间坏死性小肠结肠炎的发生率无显著差异，而GS组达到完全肠内喂养的天数和住院时间显著更长。 鉴于我们的研究表明使用GS与达到完全肠内喂养的时间延长有关，频繁使用GS值得进一步进行前瞻性研究以评估其安全性和有效性。我们推测使用GS可能是胃肠动力障碍的一个标志，因此与不良临床预后相关。
