Chan Hélène, Cougnard-Grégoire Audrey, Delyfer Marie-Noëlle, Combillet France, Rougier Marie-Bénédicte, Schweitzer Cédric, Dartigues Jean-François, Korobelnik Jean-François, Delcourt Cécile
Inserm U1219, Bordeaux Population Health Research Center, Bordeaux, France 2Université de Bordeaux, ISPED, Bordeaux, France 3CHU de Bordeaux, Service d'Ophtalmologie, Bordeaux, France.
Inserm U1219, Bordeaux Population Health Research Center, Bordeaux, France 2Université de Bordeaux, ISPED, Bordeaux, France.
Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3058-65. doi: 10.1167/iovs.16-19487.
To document reticular pseudodrusen (RPD) using multimodal imaging in French elderly subjects.
A total of 494 subjects (970 eyes) aged 77 years or more, from the Alienor study, were examined in 2011 and 2012. Reticular pseudodrusen were defined as definite if they were present with at least two imaging methods among color retinal photographs, macular cube (20° × 15°) of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and infrared reflectance (IR). The Youden index was calculated as specificity + sensitivity - 1.
The prevalence of definite RPD was 13.4% and was higher among women (15.6%) than men (10.2%). It increased with age and reached almost 50% in subjects over 85 years. Infrared reflectance was the most sensitive technique (100%) and color fundus photography the least sensitive (34.5% at left eyes and 48.1% at right eyes). The best Youden index was obtained with IR (0.96 at both eyes) followed by SD-OCT (0.87 at right eye and 0.78 at left eye). Reticular pseudodrusen were present in 4.6% of eyes without AMD, 13.0% with early AMD1, 62.6% with early AMD2, 34.6% with atrophic AMD, and 8.1% with neovascular AMD. Reticular pseudodrusen were significantly associated with central and pericentral intermediate soft drusen (odds ratio [OR]: 2.14; 95% confidence interval [CI] = 1.11-4.14 and OR: 1.49; 95% CI = 1.16-1.90, respectively) and central large soft drusen (OR: 1.67; 95% CI = 1.16-2.42).
Using multimodal imaging, the prevalence of RPD appears higher than previously reported in studies based on retinal photography only. Reticular pseudodrusen frequently accompany other signs of AMD. Infrared reflectance and SD-OCT appear to be particularly relevant methods to diagnose RPD.
使用多模态成像记录法国老年受试者的网状假性玻璃膜疣（RPD）。
2011年和2012年对来自Alienor研究的494名年龄在77岁及以上的受试者（970只眼）进行了检查。如果在彩色视网膜照片、光谱域光学相干断层扫描（SD-OCT）的黄斑立方体（20°×15°）、眼底自发荧光（FAF）和红外反射率（IR）这至少两种成像方法中均出现网状假性玻璃膜疣，则将其定义为确诊。约登指数计算为特异性+敏感性-1。
确诊RPD的患病率为13.4%，女性（15.6%）高于男性（10.2%）。患病率随年龄增长而增加，85岁以上受试者中几乎达到50%。红外反射率是最敏感的技术（100%），彩色眼底照相最不敏感（左眼为34.5%，右眼为48.1%）。红外反射率获得的约登指数最佳（双眼均为0.96），其次是SD-OCT（右眼为0.87，左眼为0.78）。在无年龄相关性黄斑变性（AMD）的眼中，4.6%存在网状假性玻璃膜疣；早期AMD1患者中为13.0%；早期AMD2患者中为62.6%；萎缩性AMD患者中为34.6%；新生血管性AMD患者中为8.1%。网状假性玻璃膜疣与中央和中央周围中间软性玻璃膜疣显著相关（优势比[OR]：分别为2.14；95%置信区间[CI]=1.11-4.14和OR：1.49；95%CI=1.16-1.90）以及中央大软性玻璃膜疣（OR：1.67；95%CI=1.16-2.42）。
使用多模态成像，RPD的患病率似乎高于之前仅基于视网膜照相的研究所报告的患病率。网状假性玻璃膜疣常伴有AMD的其他体征。红外反射率和SD-OCT似乎是诊断RPD特别相关的方法。
