Malatya Training and Research Hospital, Clinic of of Ophthalmology, Malatya, Türkiye.
Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Türkiye.
Turk J Ophthalmol. 2023 Oct 19;53(5):275-280. doi: 10.4274/tjo.galenos.2023.85616.
To investigate the presence and prevalence of reticular pseudodrusen (RPD) in patients with age-related macular degeneration using multiple imaging modalities and to compare the sensitivity and specificity of these modalities in the detection of RPD.
Images from a total of 198 consecutive patients were analyzed prospectively. Color fundus photography, red-free imaging, spectral domain optical coherence tomography (SD-OCT), infrared and blue reflectance (BR) imaging, fundus autofluorescence (FAF), enhanced-depth imaging OCT (EDI-OCT), fundus fluorescein angiography (FFA) and indocyanine green angiography were performed. RPD was diagnosed in the presence of relevant findings in at least two of the imaging methods used.
RPD were detected in 149 eyes (37.6%). In the detection of RPD, color fundus photography, red-free photography, SD-OCT, infrared, FAF, BR, and FFA imaging had sensitivity values of 50%, 57.7%, 91.6%, 95%, 74.6%, 65.7%, and 28.2% and specificity values of 99.6%, 100%, 98.4%, 94.6%, 100%, 99.6%, and 69.8%, respectively.
Infrared imaging had the highest sensitivity. SD-OCT combined with infrared imaging was the most sensitive imaging technique for detecting RPD. The high specificity of FAF, red-free, and BR imaging may be useful to confirm a diagnosis of RPD.
使用多种成像方式研究与年龄相关的黄斑变性患者中网状假性色素沉着（RPD）的存在和流行情况，并比较这些方式检测 RPD 的敏感性和特异性。
对总共 198 例连续患者的图像进行前瞻性分析。进行了彩色眼底照相、无赤光成像、谱域光相干断层扫描（SD-OCT）、红外和蓝反射（BR）成像、眼底自发荧光（FAF）、增强深度成像 OCT（EDI-OCT）、眼底荧光血管造影（FFA）和吲哚青绿血管造影。在至少两种使用的成像方法中存在相关发现的情况下诊断 RPD。
在 149 只眼中检测到 RPD（37.6%）。在检测 RPD 时，彩色眼底照相、无赤光摄影、SD-OCT、红外、FAF、BR 和 FFA 成像的敏感性分别为 50%、57.7%、91.6%、95%、74.6%、65.7%和 28.2%，特异性分别为 99.6%、100%、98.4%、94.6%、100%、99.6%和 69.8%。
红外成像具有最高的敏感性。SD-OCT 结合红外成像可能是检测 RPD 的最敏感的成像技术。FAF、无赤光和 BR 成像的高特异性可能有助于确认 RPD 的诊断。
