通过动态对比增强磁共振成像无创检测星形细胞瘤中异柠檬酸脱氢酶1基因状态
Noninvasively detecting Isocitrate dehydrogenase 1 gene status in astrocytoma by dynamic susceptibility contrast MRI.
作者信息
Tan WenLi, Xiong Ji, Huang WeiYuan, Wu JinSong, Zhan SongHua, Geng DaoYing
机构信息
Department of Radiology, Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
出版信息
J Magn Reson Imaging. 2017 Feb;45(2):492-499. doi: 10.1002/jmri.25358. Epub 2016 Jul 1.
PURPOSE
To investigate the value of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) in the noninvasive evaluation of isocitrate dehydrogenase (IDH) 1 gene status in astrocytoma.
MATERIALS AND METHODS
The preoperative DSC MRI data of 91 lesions with pathologically confirmed astrocytoma were retrospectively analyzed. MR examination was performed on a 3T MRI scanner. The normalized maximum ratios of relative cerebral blood volume (rCBV ratio) of tumor parenchyma were measured. The enrolled astrocytoma patients were divided into six groups according to the World Health Organization (WHO) classification method and IDH1 gene status. The differences in the rCBV ratio of tumor parenchyma between the IDH1 gene mutant and wildtype groups of WHO grade II, III, and IV were compared and plotted receiver operating characteristic (ROC) curves were drawn.
RESULTS
The IDH1 gene mutant and wildtype groups of WHO grade II, III, and IV astrocytoma showed differences in the rCBV ratio (P = 0.005, 0.045, and 0.005, respectively). In WHO grade II, III, and IV astrocytoma, the area under the ROC curve was respectively 0.83, 0.86, and 0.94. The cutoff value of the rCBV ratio was respectively 2.20, 3.14, and 5.63.
CONCLUSION
The rCBV ratio value provided by DSC MRI provides a new potential imaging method for the noninvasive evaluation of the IDH1 status in astrocytoma.
LEVEL OF EVIDENCE
3 J. Magn. Reson. Imaging 2017;45:492-499.
目的
探讨动态磁敏感对比增强（DSC）磁共振成像（MRI）在无创评估星形细胞瘤异柠檬酸脱氢酶（IDH）1基因状态中的价值。
材料与方法
回顾性分析91例经病理证实的星形细胞瘤病变的术前DSC MRI数据。在3T MRI扫描仪上进行MR检查。测量肿瘤实质相对脑血容量（rCBV比值）的标准化最大比值。根据世界卫生组织（WHO）分类方法和IDH1基因状态，将纳入的星形细胞瘤患者分为六组。比较WHO二级、三级和四级IDH1基因突变型和野生型组肿瘤实质rCBV比值的差异，并绘制受试者操作特征（ROC）曲线。
结果
WHO二级、三级和四级星形细胞瘤的IDH1基因突变型和野生型组在rCBV比值上存在差异（分别为P = 0.005、0.045和0.005）。在WHO二级、三级和四级星形细胞瘤中，ROC曲线下面积分别为0.83、0.86和0.94。rCBV比值的截断值分别为2.20、3.14和5.63。
结论
DSC MRI提供的rCBV比值为无创评估星形细胞瘤IDH1状态提供了一种新的潜在成像方法。
证据水平
3 J. Magn. Reson. Imaging 2017;45:492 - 499。
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