未结合型高胆红素血症中的血红素生物合成：在冈恩大鼠模型中的观察

Haem biosynthesis in the unconjugated hyperbilirubinaemias: observations in the Gunn rat model.

作者信息

Graham A M, McColl K E, Moore M R

机构信息

University Department of Medicine, Western Infirmary, Glasgow, Scotland.

出版信息

Clin Biochem. 1989 Jun;22(3):177-9. doi: 10.1016/s0009-9120(89)80074-8.

DOI:10.1016/s0009-9120(89)80074-8

PMID:2736771

Abstract

Disturbances of the enzymes of haem biosynthesis have been reported in patients with unconjugated hyperbilirubinaemia. We have examined the excretion of haem precursors in the Gunn rat which suffers from severe unconjugated hyperbilirubinaemia. In urine, levels of aminolaevulinic acid and total porphyrin were significantly reduced when compared to controls. In feces both coproporphyrin and protoporphyrin levels were reduced in Gunn rats, the former being more affected. Blood porphyrin levels in control and Gunn rats were similar.

摘要

据报道，未结合型高胆红素血症患者存在血红素生物合成酶紊乱的情况。我们研究了患有严重未结合型高胆红素血症的冈恩大鼠中血红素前体的排泄情况。与对照组相比，尿液中δ-氨基乙酰丙酸和总卟啉水平显著降低。在粪便中，冈恩大鼠的粪卟啉和原卟啉水平均降低，前者受影响更大。对照组和冈恩大鼠的血液卟啉水平相似。