用于鉴定天然产物中生物活性化合物的分析技术比较。
Comparison of analytical techniques for the identification of bioactive compounds from natural products.
作者信息
Cieśla Łukasz, Moaddel Ruin
机构信息
Laboratory of Clinical Investigation, Biomedical Research Center, 8C232, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA.
出版信息
Nat Prod Rep. 2016 Oct 28;33(10):1131-45. doi: 10.1039/c6np00016a. Epub 2016 Jul 1.
Abstract
Covering: 2000 to 2016Natural product extracts are a rich source of bioactive compounds. As a result, the screening of natural products for the identification of novel biologically active metabolites has been an essential part of several drug discovery programs. It is estimated that more than 70% of all drugs approved from 1981 and 2006, were either derived from or structurally similar to nature based compounds indicating the necessity for the development of a rapid method for the identification of novel compounds from plant extracts. The screening of biological matrices for the identification of novel modulators is nevertheless still challenging. In this review we discuss current techniques in phytochemical analysis and the identification of biologically active components.
摘要
涵盖时间
2000年至2016年
天然产物提取物是生物活性化合物的丰富来源。因此，筛选天然产物以鉴定新型生物活性代谢物一直是多个药物发现项目的重要组成部分。据估计，1981年至2006年批准的所有药物中，超过70%要么源自天然化合物，要么在结构上与天然化合物相似，这表明有必要开发一种从植物提取物中快速鉴定新型化合物的方法。然而，筛选生物基质以鉴定新型调节剂仍然具有挑战性。在本综述中，我们讨论了植物化学分析和生物活性成分鉴定的当前技术。
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