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两名低补体血症性膜增生性肾小球肾炎患者血清中的C3肾炎因子和C4肾炎因子

C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis.

作者信息

Tanuma Y, Ohi H, Watanabe S, Seki M, Hatano M

机构信息

Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Clin Exp Immunol. 1989 Apr;76(1):82-5.

PMID:2736802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541731/
Abstract

Both C3 nephritic factor (C3NeF) and C4 nephritic factor (C4NeF) were found in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis type 1 (H-MPGN type 1). Both stabilizing activities were associated with the IgG fraction. The serum levels of C3 and C5 were quite low, whereas the levels of early components and control proteins were in the normal range.

摘要

在两名1型低补体血症性膜增生性肾小球肾炎（H-MPGN 1型）患者的血清中发现了C3肾炎因子（C3NeF）和C4肾炎因子（C4NeF）。两种稳定活性均与IgG组分相关。C3和C5的血清水平相当低，而早期补体成分和对照蛋白的水平在正常范围内。

相似文献

1
C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis.两名低补体血症性膜增生性肾小球肾炎患者血清中的C3肾炎因子和C4肾炎因子
Clin Exp Immunol. 1989 Apr;76(1):82-5.
2
Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN).膜增生性肾小球肾炎（MPGN）中C3肾炎因子和C4肾炎因子的出现情况。
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3
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本文引用的文献

1
Biological significance of the C3 nephritic factor in membranoproliferative glomerulonephritis.C3肾炎因子在膜增生性肾小球肾炎中的生物学意义。
Clin Nephrol. 1982 Nov;18(5):240-6.
2
Relative resistance of the F-42-stabilized classical pathway C3 convertase to inactivation by C4-binding protein.F-42稳定的经典途径C3转化酶对C4结合蛋白介导的失活作用的相对抗性
J Immunol. 1980 Nov;125(5):2051-4.
3
Stabilization of the classical pathway C3 convertase C42, by a factor F-42, isolated from serum of patients with systemic lupus erythematosus.从系统性红斑狼疮患者血清中分离出的一种因子F - 42对经典途径C3转化酶C42的稳定作用。
Immunology. 1980 Jul;40(3):417-24.
4
Nephritic factor of the classical pathway of complement: immunoglobulin G autoantibody directed against the classical pathway C3 convetase enzyme.补体经典途径的肾炎因子：针对经典途径C3转化酶的免疫球蛋白G自身抗体。
J Clin Invest. 1980 Jun;65(6):1249-56. doi: 10.1172/jci109787.
5
A new method for the preparation of EAC14 cell with human or guinea-pig serum.一种用人或豚鼠血清制备EAC14细胞的新方法。
J Immunol Methods. 1974 Aug;5(3):307-17. doi: 10.1016/0022-1759(74)90117-3.
6
Complement and the kidney.补体与肾脏
Proc R Soc Med. 1972 Dec;65(12):1095-8. doi: 10.1177/003591577206501221.
7
Serum C'3 lytic system in patients with glomerulonephritis.肾小球肾炎患者的血清补体C3溶解系统
Science. 1969 Apr 25;164(3878):436-7. doi: 10.1126/science.164.3878.436.
8
C4 nephritic factor in a patient with chronic glomerulonephritis.一名慢性肾小球肾炎患者体内的C4肾炎因子
J Clin Lab Immunol. 1987 Feb;22(2):65-70.
9
Regulation and deregulation of the fluid-phase classical pathway C3 convertase.液相经典途径C3转化酶的调节与去调节
J Immunol. 1985 Jul;135(1):440-4.
10
C3 nephritic factor (C3NeF): stabilization of fluid phase and cell-bound alternative pathway convertase.C3肾炎因子（C3NeF）：液相和细胞结合的替代途径转化酶的稳定作用。
J Immunol. 1976 Jan;116(1):1-7.