肾小球肾炎患者的血清补体C3溶解系统
Serum C'3 lytic system in patients with glomerulonephritis.
作者信息
Spitzer R E, Vallota E H, Forristal J, Sudora E, Stitzel A, Davis N C, West C D
出版信息
Science. 1969 Apr 25;164(3878):436-7. doi: 10.1126/science.164.3878.436.
PMID:4180576
Abstract
The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C'3 is 80 to 90 percent complete in 20 minutes at 37 degrees C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.
摘要
低补体血症性肾小球肾炎患者的血清含有一种物质，该物质在镁离子存在下与正常血清辅助因子结合，特异性裂解补体第三成分。在37℃和pH值为7的条件下，20分钟内C'3的这种裂解完成80%至90%。肾炎因子及其辅助因子均无法与补体系统明确关联。
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