Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Cell. 2016 Jun 30;166(1):9-10. doi: 10.1016/j.cell.2016.06.035.
T-lymphocytes show large changes in ATP demand and nutrient utilization, imposed by their different roles as T memory and T effector cells. Therefore, T cell remodeling represents a bioenergetic challenge to mitochondria. New work from Buck et al. links changes in mitochondrial shape to T cell fate choice.
T 淋巴细胞的 ATP 需求和营养利用发生了巨大变化，这是由它们作为 T 记忆细胞和 T 效应细胞的不同作用所决定的。因此，T 细胞重塑对线粒体是一个能量挑战。Buck 等人的新工作将线粒体形状的变化与 T 细胞命运选择联系起来。
