van Laar Peter Jan, Oterdoom D L Marinus, Ter Horst Gert J, van Hulzen Arjen L J, de Graaf Eva K L, Hoogduin Hans, Meiners Linda C, van Dijk J Marc C
Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
World Neurosurg. 2016 Sep;93:410-2. doi: 10.1016/j.wneu.2016.06.084. Epub 2016 Jun 29.
In deep brain stimulation (DBS), accurate placement of the lead is critical. Target definition is highly dependent on visual recognition on magnetic resonance imaging (MRI). We prospectively investigated whether the 7-T MRI enabled better visualization of targets and led to better placement of leads compared with the 1.5-T and the 3-T MRI.
Three patients with PD (mean, 55 years) were scanned on 1.5-, 3-, and 7-T MRI before surgery. Tissue contrast and signal-to-noise ratio were measured. Target coordinates were noted on MRI and during surgery. Differences were analyzed with post-hoc analysis of variance.
The 7-T MRI demonstrated a significant improvement in tissue visualization (P < 0.005) and signal-to-noise ratio (P < 0.005). However, no difference in the target coordinates was found between the 7-T and the 3-T MRI.
Although the 7-T MRI enables a significant better visualization of the DBS target in patients with PD, we found no clinical benefit for the placement of the DBS leads.
在脑深部电刺激（DBS）中，电极的精确放置至关重要。靶点的定义高度依赖于磁共振成像（MRI）上的视觉识别。我们前瞻性地研究了与1.5-T和3-T MRI相比，7-T MRI是否能更好地显示靶点并实现电极的更好放置。
3例帕金森病患者（平均55岁）在手术前接受了1.5-T、3-T和7-T MRI扫描。测量组织对比度和信噪比。在MRI上和手术过程中记录靶点坐标。采用事后方差分析来分析差异。
7-T MRI在组织可视化（P < 0.005）和信噪比（P < 0.005）方面有显著改善。然而，7-T和3-T MRI之间在靶点坐标上未发现差异。
虽然7-T MRI能显著更好地显示帕金森病患者的DBS靶点，但我们发现其对DBS电极的放置并无临床益处。
