Ben Nsir Atef, Hadhri Rym, Kilani Mohamed, Chabaane Mohamed, Darmoul Mehdi, Hattab Nejib
Department of Neurosurgery, Fattouma Bourguiba University Hospital, The University of Medicine of Monastir, Monastir, Tunisia.
Department of Pathology, Fattouma Bourguiba University Hospital, The University of Medicine of Monastir, Monastir, Tunisia.
World Neurosurg. 2016 Sep;93:488.e5-7. doi: 10.1016/j.wneu.2016.06.090. Epub 2016 Jun 29.
Venous angioma is an extremely rare vascular malformation of the epidural space. To the best of our knowledge, only 5 cases have been documented to date and none has been reported in the setting of a previous malignancy.
We report the case of a 42-year-old woman with a previous history of ovarian cancer, treated by surgery plus chemotherapy; who presented with signs of spinal cord compression for 3 weeks. Magnetic resonance imaging showed an intensely enhancing epidural mass at the T2-T6 level causing major spinal cord compression, for which urgent surgery was indicated. During surgery, the tumor was extremely hemorrhagic and the hemostasis was hazardous. Blood loss was estimated at 1.5 L, causing hemodynamic instability and requiring intensive resuscitation with fluids and blood transfusions. Gross total resection was achieved and the pathologic examination confirmed the diagnosis of venous angioma. The patient recovered quickly postoperatively and was able to walk independently within 2 weeks of starting intensive rehabilitation. She was symptom free with no clinical or radiologic evidence of recurrence at 1 year follow-up.
Venous angioma should be included in the differential diagnosis of spinal epidural masses even in case of previous malignancy. Subtle imaging features should alert clinicians to this rare yet potentially life-threatening condition. Surgery remains the cornerstone of the treatment and can result in remarkable recovery.
静脉性血管瘤是一种极为罕见的硬膜外间隙血管畸形。据我们所知,迄今为止仅有5例病例被记录,且此前无在恶性肿瘤背景下发生的相关报道。
我们报告了一例42岁女性患者,既往有卵巢癌病史,接受过手术及化疗;该患者出现脊髓压迫症状3周。磁共振成像显示T2 - T6水平有一个强化明显的硬膜外肿块,导致严重脊髓压迫,因此需要紧急手术。手术过程中,肿瘤出血极其严重,止血困难。估计失血量为1.5升,导致血流动力学不稳定,需要大量补液及输血进行强化复苏。实现了肿瘤全切,病理检查确诊为静脉性血管瘤。患者术后恢复迅速,在开始强化康复治疗2周内即可独立行走。随访1年时,患者无症状,无临床及影像学复发证据。
即使在既往有恶性肿瘤的情况下,静脉性血管瘤也应纳入脊髓硬膜外肿块的鉴别诊断。细微的影像学特征应提醒临床医生注意这种罕见但可能危及生命的疾病。手术仍然是治疗的基石,可带来显著恢复。